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Chroman 1 dihydrochloride

70 Cited Publications
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Based on 70 publication(s) in Google Scholar

Chroman 1 dihydrochloride is a highly potent and selective ROCK inhibitor. Chroman 1 dihydrochloride is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 dihydrochloride also has inhibitory activity against MRCK, with an IC50 of 150 nM.

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  • 純度: 98.13%
  • 分子式: C24H30Cl2N4O4
  • 分子量:509.43
  • 保管条件:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Chroman 1 dihydrochloride Chemical Structure
    Chroman 1 dihydrochloride 構造式
  • Experimental Validation Results for Chroman 1 dihydrochloride
  • Experimental Validation Results for Chroman 1 dihydrochloride
  • Experimental Validation Results for Chroman 1 dihydrochloride
  • Experimental Validation Results for Chroman 1 dihydrochloride
  • Experimental Validation Results for Chroman 1 dihydrochloride
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  • Chroman 1 dihydrochloride Chemical Structure
    Chroman 1 dihydrochloride Chemical Structure
    1/16
  • 1/16

    Chroman 1 dihydrochloride purchased from MedChemExpress. Usage Cited in: J Med Virol. 2024 Apr;96(4):e29579. [Abstract]

    Customer Validation
     Chroman 1 (50 nM; 24 h). Survivals of differentiated hiPSCs - anterior foregut endoderm (left) and AOs (right) were improved with CEPT cocktail (Chroman 1, Emricasan, Polyamines and trans-ISRIB) treatment compared to Y27632. Phase contrast images were taken after 24 h of seeding (hiPSC) and 8 days of seeding (AOs).

  • 1/16

    Chroman 1 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Protoc. 2023 Jan;18(1):58-80. [Abstract]

    Customer Validation
     Chroman 1 (50 nM; 5 min). Fast-acting CEPT (Chroman 1, Emricasan, Polyamines, trans-ISRIB) is cytoprotective and maintains cell morphology of WA09 dissociated cells, whereas ongoing cell contractions lead to abnormal cells in the presence of Y-27632.

  • 1/16

    Chroman 1 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Methods. 2021 May;18(5):528-541. [Abstract]

    Customer Validation
     Improved survival of hESCs (WA09) with Chroman 1 (50 nM; 24 h) treatment.

  • 1/16

    Chroman 1 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Methods. 2021 May;18(5):528-541. [Abstract]

    Customer Validation
     Chroman 1 (50 nM; 24 h). hESCs (WA09) cells were dissociated with Accutase and plated on VN in E8 medium. CTG was used to quantify viable cells 24 h post-seeding.

  • 1/16

    Chroman 1 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Methods. 2021 May;18(5):528-541. [Abstract]

    Customer Validation
     Chroman 1 (50 nM; 24 h). Total caspase-3 expression in hESCs (WA09) in comparison to their lineage-committed precursors after directed differentiation into ectoderm (PAX6), mesoderm (Brachyury), and endoderm (SOX17). Note that caspase-3 is strongly expressed in the pluripotent state and downregulated upon differentiation.

  • Chroman 1 dihydrochloride