2. Recombinant Proteins
  3. Cytokines and Growth Factors CD Antigens
  4. CSF & Receptors Macrophage CD Proteins Monocyte CD Proteins Endothelial cell CD Proteins
  5. GM-CSFR GM-CSF R alpha/CD116
  6. GM-CSF R alpha
  7. GM-CSF R alpha Protein, Cynomolgus (298.a.a, HEK293, His)

GM-CSF R alpha Protein, Cynomolgus (298.a.a, HEK293, His)

Cat. No.: HY-P700730
Handling Instructions

GM-CSF R alpha Protein, a crucial type I cytokine receptor in the Type 5 subfamily, plays an essential role in mediating cellular responses to various cytokines. Sharing conserved features with related receptors, it transduces signals from specific type I cytokines, emphasizing its unique contributions to hematopoiesis and immune regulation within the broader context of cell signaling. Understanding GM-CSF R alpha's role holds promise for therapeutic interventions in hematopoietic disorders and immune dysregulation. GM-CSF R alpha Protein, Cynomolgus (298.a.a, HEK293, His) is the recombinant cynomolgus-derived GM-CSF R alpha protein, expressed by HEK293, with C-His labeled tag. The total length of GM-CSF R alpha Protein, Cynomolgus (298.a.a, HEK293, His) is 298 a.a., with molecular weight of 60-70 kDa.

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Description

GM-CSF R alpha Protein, a crucial type I cytokine receptor in the Type 5 subfamily, plays an essential role in mediating cellular responses to various cytokines. Sharing conserved features with related receptors, it transduces signals from specific type I cytokines, emphasizing its unique contributions to hematopoiesis and immune regulation within the broader context of cell signaling. Understanding GM-CSF R alpha's role holds promise for therapeutic interventions in hematopoietic disorders and immune dysregulation. GM-CSF R alpha Protein, Cynomolgus (298.a.a, HEK293, His) is the recombinant cynomolgus-derived GM-CSF R alpha protein, expressed by HEK293, with C-His labeled tag. The total length of GM-CSF R alpha Protein, Cynomolgus (298.a.a, HEK293, His) is 298 a.a., with molecular weight of 60-70 kDa.
Background

The GM-CSF R alpha Protein is a critical member of the type I cytokine receptor family, specifically categorized within the Type 5 subfamily, highlighting its essential role in mediating cellular responses to various cytokines. As part of this receptor family, GM-CSF R alpha likely shares conserved structural and functional features with related receptors, emphasizing its involvement in transducing signals from specific type I cytokines. The classification within the type I cytokine receptor family underscores its specific designation within the broader context of cell signaling, providing insights into its unique contributions to hematopoiesis and immune regulation. The study of GM-CSF R alpha contributes to our understanding of its role in physiological processes, offering potential applications in therapeutic interventions for conditions related to hematopoietic disorders and immune dysregulation. Further exploration of GM-CSF R alpha's role holds promise for enhancing our knowledge of its contributions to both normal cellular function and pathological conditions.
Species

Cynomolgus
Source

HEK293
Tag

C-His
Accession

A0A2K5UC70 (L20-S317)
Gene ID

/
Molecular Construction
N-term
GM-CSF R alpha (L20-S317)
Accession # A0A2K5UC70
His
C-term
Synonyms
GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha; CSF2R; CSF2RY; CSF2RA; CDw116; CD116; CSF2RAX; CSF2RAY; CSF2RX; GMCSFR; GMR; SMDP4
Molecular Weight

60-70 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

GM-CSF R alpha Protein, Cynomolgus (298.a.a, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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