Toyocamycin (Standard) (Synonyms: Vengicide (Standard))

Cat. No.: HY-103248R: Data Sheet Handling Instructions
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DL-Aspartic acid (Standard) is the analytical standard of DL-Aspartic acid. This product is intended for research and analytical applications. DL-Aspartic acid (DL-Asp-OH) is a kind of biological materials or organic compounds that are widely used in life science research.

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Toyocamycin (Standard) Chemical Structure

CAS No. : 606-58-6

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5 mg	Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 80 nM (XBP1 activation)^[1]; 79 nM (CDK9); 2.8 μM (CDK7); 0.67 μM (CDK2), 15 μM (CDK4), >10 μM (CDK6)^[2]

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	3.3 μg/mL Compound: toyocamycin	Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting	[PMID: 1666120]
B16	EC₅₀	0.005 μM Compound: toyocamycin	Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay. Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay.	[PMID: 11020285]
BSC-1	IC₅₀	46 μM Compound: a	Tested in vitro for cytotoxicity against the monkey kidney cells (BSC-1 cells). Tested in vitro for cytotoxicity against the monkey kidney cells (BSC-1 cells).	[PMID: 2175356]
HFF	IC₅₀	0.03 μM Compound: 8b	Cytotoxicity was evaluated against the Human diploid cells (HFF) Cytotoxicity was evaluated against the Human diploid cells (HFF)	[PMID: 2913300]
HFF	IC₅₀	0.03 μM Compound: A	Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration. Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration.	[PMID: 7562947]
HFF	IC₅₀	0.3 μM Compound: 2	Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration. Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration.	[PMID: 7562947]
HFF	IC₅₀	8 μM Compound: 6	Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration. Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration.	[PMID: 7562947]
HFF	IC₅₀	8 μM Compound: a	Tested in vitro for cytotoxicity against the normal human diploid cells (HFF cells). Tested in vitro for cytotoxicity against the normal human diploid cells (HFF cells).	[PMID: 2175356]
HFF	IC₅₀	< 0.01 μM Compound: I	Cytotoxicity against HFF cells, estimated by visual scoring of cells not affected by virus infection in the plaque reduction assay Cytotoxicity against HFF cells, estimated by visual scoring of cells not affected by virus infection in the plaque reduction assay	[PMID: 8632411]
KB	IC₅₀	0.03 μM Compound: A	In vitro inhibition of KB cell proliferation. In vitro inhibition of KB cell proliferation.	[PMID: 7562947]
KB	IC₅₀	0.03 μM Compound: I	Cytotoxic activity tested against exponentially growing KB cells, determined by staining method Cytotoxic activity tested against exponentially growing KB cells, determined by staining method	[PMID: 8632411]
KB	IC₅₀	0.04 μM Compound: 8b	Cytotoxicity was evaluated in Human neoplastic cell line (KB) Cytotoxicity was evaluated in Human neoplastic cell line (KB)	[PMID: 2913300]
KB	IC₅₀	0.1 μM Compound: 2	In vitro inhibition of KB cell proliferation. In vitro inhibition of KB cell proliferation.	[PMID: 7562947]
KB	IC₅₀	17 μM Compound: 6	In vitro inhibition of KB cell proliferation. In vitro inhibition of KB cell proliferation.	[PMID: 7562947]
KB	IC₅₀	17 μM Compound: a	Tested in vitro for cytotoxicity against the human neoplastic cell line (KB cells). Tested in vitro for cytotoxicity against the human neoplastic cell line (KB cells).	[PMID: 2175356]
L1210	IC₅₀	0.0026 μg/mL Compound: 2	Cytotoxicity against mouse L1210 cells Cytotoxicity against mouse L1210 cells	[PMID: 2693614]
L1210	IC₅₀	0.004 μM Compound: A	Inhibition of L1210 murine leukemic cells proliferation in vitro Inhibition of L1210 murine leukemic cells proliferation in vitro	[PMID: 7562947]
L1210	IC₅₀	0.1 μM Compound: 2	Inhibition of L1210 murine leukemic cells proliferation in vitro Inhibition of L1210 murine leukemic cells proliferation in vitro	[PMID: 7562947]
L1210	IC₅₀	4 x 10^-9 M Compound: 8b	In vitro cytotoxicity was evaluated against the L1210 Murine leukemic cells In vitro cytotoxicity was evaluated against the L1210 Murine leukemic cells	[PMID: 2913300]
Vero C1008	EC₅₀	0.59 μM Compound: Toyocamycin	Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in infection measured after 24 hrs by Plaque assay Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as reduction in infection measured after 24 hrs by Plaque assay	[PMID: 37229831]

Molecular Weight

291.26

Formula

C₁₂H₁₃N₅O₄

CAS No.

606-58-6

SMILES

O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2

Structure Classification

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Toyocamycin, et al. Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood Cancer J. 2012 Jul;2(7):e79. [Content Brief]

[2]. Pandey S, et al. Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells. Cancers (Basel). 2022 Jul 8;14(14):3340. [Content Brief]

[3]. Park SG, et al. Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells. Pharmacol Rep. 2017 Feb;69(1):90-96. [Content Brief]

Toyocamycin (Standard) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Toyocamycin (Standard) (Synonyms: Vengicide (Standard))

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Toyocamycin (Standard) Related Antibodies

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Biological Activity

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Customer Review

Toyocamycin (Standard) Related Classifications

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The molarity calculator equation

The dilution calculator equation

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