1. Cell Cycle/DNA Damage
  2. IRE1

B I09 

Cat. No.: HY-107400
Handling Instructions

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

For research use only. We do not sell to patients.

B I09 Chemical Structure

B I09 Chemical Structure

CAS No. : 1607803-67-7

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  • Biological Activity

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  • Technical Information

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  • References

Description

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

IC50 & Target

IC50: 1230 nM (IRE-1 RNase)[1].

In Vitro

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM[1]. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells[2].

In Vivo

B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2970 mL 16.4848 mL 32.9696 mL
5 mM 0.6594 mL 3.2970 mL 6.5939 mL
10 mM 0.3297 mL 1.6485 mL 3.2970 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[2]

Mice[2]
Mice are intraperitoneally injected with B I09 (50 mg/kg) on the first 5 days of each week for 3 weeks[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

303.31

Formula

C₁₆H₁₇NO₅

CAS No.

1607803-67-7

SMILES

OC1=CC=C(C2=C(CNCC2)C3=O)C(O3)=C1C4OCCCO4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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B I09
Cat. No.:
HY-107400
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B I09

Cat. No.: HY-107400