1. Cell Cycle/DNA Damage
  2. IRE1

B I09 

Cat. No.: HY-107400
Handling Instructions

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

For research use only. We do not sell to patients.

B I09 Chemical Structure

B I09 Chemical Structure

CAS No. : 1607803-67-7

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  • Biological Activity

  • Protocol

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B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

IC50 & Target

IC50: 1230 nM (IRE-1 RNase)[1].

In Vitro

B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM[1]. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. B I09 is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells[2].

In Vivo

B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis and do not cause systemic toxicity[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2970 mL 16.4848 mL 32.9696 mL
5 mM 0.6594 mL 3.2970 mL 6.5939 mL
10 mM 0.3297 mL 1.6485 mL 3.2970 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Mice are intraperitoneally injected with B I09 (50 mg/kg) on the first 5 days of each week for 3 weeks[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight









Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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B I09
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B I09

Cat. No.: HY-107400