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Cat. No.: HY-107400R

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B I09 (Standard)

Name: B I09 (Standard)
Brand: MedChemExpress
SKU: HY-107400R
Price: 120.00 USD
Availability: InStock
Rating: 5 (1 reviews)

B I09 (Standard) is the analytical standard of B I09 (HY-107400). This product is intended for research and analytical applications. B I09 is an IRE-1 RNase inhibitor, with an IC₅₀ of 1230 nM.

For research use only. We do not sell to patients.

CAS No.: 1607803-67-7
Formula: C₁₆H₁₇NO₅
Molecular Weight:303.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

B I09 (Standard) Chemical Structure

CAS No.: 1607803-67-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

B I09 (Standard) is the analytical standard of B I09 (HY-107400). This product is intended for research and analytical applications. B I09 is an IRE-1 RNase inhibitor, with an IC₅₀ of 1230 nM.

IC₅₀ & Target

IC50: 1230 nM (IRE-1 RNase)^[1].

Chemical Information

CAS No. 1607803-67-7
Molecular Weight 303.31
Formula C₁₆H₁₇NO₅
SMILES

OC1=CC=C(C2=C(CNCC2)C3=O)C(O3)=C1C4OCCCO4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ranatunga S, et al. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57(10):4289-301. [Content Brief]

[2]. Tang CH, et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014 Jun;124(6):2585-98. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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