3,6-DMAD hydrochloride
Based on 1 publication(s) in Google Scholar
3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.50%
- Formula: C22H31N5
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) 3,6-DMAD hydrochloride
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Biological Activity
3,6-DMAD hydrochloride (0-6 μM; 24 h; RPMI 8226 and MM1.R human MM cells) has cytotoxicity against MM cell lines[1].
3,6-DMAD hydrochloride (0-30 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits XBP1 splicing (XBP1s) in a dose dependent manner[1].
3,6-DMAD hydrochloride (0.1-500 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits IRE1α endonuclease activity[1].
3,6-DMAD hydrochloride (1-60 μM; 2 h; HEK293 cells) inhibits IRE1α oligomerization and IRE1α-GFP foci formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RPMI 8226 and MM1.R human MM cells
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Concentration:0, 0.5, 1, 2, 3, 4, 5 and 6 μM
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Incubation Time:24 hours
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Result:Inhibited cell survival rate in a dose dependent manner.
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Cell Line:HT1080 cells treated with Tg (0.3 μM)
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Concentration:0, 5, 10 and 30 μM
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Incubation Time:14 hours
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Result:Showed XBP1s inhibition at as low as 0.5 μM.
3,6-DMAD hydrochloride (10 mg/kg; 24 h; i.p.; every 48 hours, for 12 days; NOD Scid mice with RPMI 8226 xenograft) suppresses multiple myeloma xenograft growth in vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; three times every 12 hours, for 84 hours
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Result:Inhibited XBP1-luciferase activity in NOD Scid mice with RPMI 8226 xenograft.
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Animal Model:NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; every 48 hours, for 12 days
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Result:Inhibited tumor growth in NOD Scid mice with RPMI 8226 xenograft.
Chemical Information
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Appearance Solid
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Formula C22H31N5
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Color Yellow to brown
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SMILES
CN(C1=CC=C2C(N=C3C=C(C=CC3=C2NCCCN(C)C)N(C)C)=C1)C.[x HCl]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
SHP2 improves ovarian morphology and steroidogenic function in a rat PCOS model by modulating IRE1α/XBP1/NLRP3-mediated granulosa cell pyroptosis. [Abstract]2026 Mar 21;16(1):14376. PMID: 41865134
Solvent & Solubility
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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