1. Cell Cycle/DNA Damage
  2. IRE1
  3. 3,6-DMAD dihydrochloride

3,6-DMAD dihydrochloride 

Cat. No.: HY-U00460B
Handling Instructions

3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer.

For research use only. We do not sell to patients.

3,6-DMAD dihydrochloride Chemical Structure

3,6-DMAD dihydrochloride Chemical Structure

CAS No. : 2226511-77-7

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Description

3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer[1][2].

In Vitro

3,6-DMAD dihydrochloride (0-6 μM; 24 h; RPMI 8226 and MM1.R human MM cells) has cytotoxicity against MM cell lines[1].
3,6-DMAD dihydrochloride (0-30 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits XBP1 splicing (XBP1s) in a dose dependent manner[1].
3,6-DMAD dihydrochloride (0.1-500 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits IRE1α endonuclease activity[1].
3,6-DMAD dihydrochloride (1-60 μM; 2 h; HEK293 cells) inhibits IRE1α oligomerization and IRE1α-GFP foci formation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: RPMI 8226 and MM1.R human MM cells
Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 6 μM
Incubation Time: 24 hours
Result: Inhibited cell survival rate in a dose dependent manner.

Cell Viability Assay[1]

Cell Line: 0, 5, 10 and 30 μM
Concentration: 0, 0.5, 1, 2, 3, 4, 5 and 6 μM24 hours
Incubation Time: 14 hours
Result: Showed XBP1s inhibition at as low as 0.5 μM.
In Vivo

3,6-DMAD dihydrochloride (10 mg/kg; i.p.; three times every 12 hours, for 84 hours; NOD Scid mice with RPMI 8226 xenograft) has inhibition of XBP1 splicing in vivo[1].
3,6-DMAD dihydrochloride (10 mg/kg; 24 h; i.p.; every 48 hours, for 12 days; NOD Scid mice with RPMI 8226 xenograft) suppresses multiple myeloma xenograft growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; three times every 12 hours, for 84 hours
Result: Inhibited XBP1-luciferase activity in NOD Scid mice with RPMI 8226 xenograft.
Animal Model: NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; every 48 hours, for 12 days
Result: Inhibited tumor growth in NOD Scid mice with RPMI 8226 xenograft.
Molecular Weight

438.44

Formula

C22H33Cl2N5

CAS No.
SMILES

CN(C)CCCNC1=C2C=CC(N(C)C)=CC2=NC3=C1C=CC(N(C)C)=C3.Cl.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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3,6-DMAD dihydrochloride
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HY-U00460B
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