3,6-DMAD dihydrochloride
Based on 1 publication(s) in Google Scholar
3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2226511-77-7
- Formula: C22H33Cl2N5
- Molecular Weight:438.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) 3,6-DMAD dihydrochloride
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Biological Activity
3,6-DMAD dihydrochloride (0-6 μM; 24 h; RPMI 8226 and MM1.R human MM cells) has cytotoxicity against MM cell lines[1].
3,6-DMAD dihydrochloride (0-30 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits XBP1 splicing (XBP1s) in a dose dependent manner[1].
3,6-DMAD dihydrochloride (0.1-500 μM; 14 h; HT1080 cells treated with Tg (0.3 μM)) inhibits IRE1α endonuclease activity[1].
3,6-DMAD dihydrochloride (1-60 μM; 2 h; HEK293 cells) inhibits IRE1α oligomerization and IRE1α-GFP foci formation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RPMI 8226 and MM1.R human MM cells
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Concentration:0, 0.5, 1, 2, 3, 4, 5 and 6 μM
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Incubation Time:24 hours
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Result:Inhibited cell survival rate in a dose dependent manner.
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Cell Line:0, 5, 10 and 30 μM
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Concentration:0, 0.5, 1, 2, 3, 4, 5 and 6 μM24 hours
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Incubation Time:14 hours
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Result:Showed XBP1s inhibition at as low as 0.5 μM.
3,6-DMAD dihydrochloride (10 mg/kg; 24 h; i.p.; every 48 hours, for 12 days; NOD Scid mice with RPMI 8226 xenograft) suppresses multiple myeloma xenograft growth in vivo[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; three times every 12 hours, for 84 hours
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Result:Inhibited XBP1-luciferase activity in NOD Scid mice with RPMI 8226 xenograft.
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Animal Model:NOD Scid mice (4-6 weeks) with RPMI 8226 xenograft[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; every 48 hours, for 12 days
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Result:Inhibited tumor growth in NOD Scid mice with RPMI 8226 xenograft.
Chemical Information
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CAS No. 2226511-77-7
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Molecular Weight 438.44
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Formula C22H33Cl2N5
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SMILES
CN(C)CCCNC1=C2C=CC(N(C)C)=CC2=NC3=C1C=CC(N(C)C)=C3.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
SHP2 improves ovarian morphology and steroidogenic function in a rat PCOS model by modulating IRE1α/XBP1/NLRP3-mediated granulosa cell pyroptosis. [Abstract]2026 Mar 21;16(1):14376. PMID: 41865134
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3,6-DMAD dihydrochloride Related Classifications
HY-U00460B Related Classifications
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