2226511-77-7
2226511-77-7
Chemical Structure
3,6-DMAD dihydrochloride
- CAS No.: 2226511-77-7
- Formula:C22H33Cl2N5
- Molecular Weight:438.44
IUPAC Name: N9-(3-(dimethylamino)propyl)-N3,N3,N6,N6-tetramethylacridine-3,6,9-triamine dihydrochloride
InChIKey: QFTZLLNIVBXXJG-UHFFFAOYSA-N
SMILES: CN(C)CCCNC1=C2C=CC(N(C)C)=CC2=NC3=C1C=CC(N(C)C)=C3.Cl.Cl
Biological Activity: 3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer[1][2].
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3,6-DMAD dihydrochloride | 3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer. | |||||||||||||||||||||
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References
- [1]. Jiang D, et, al. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 Sep;15(9):2055-65. [Content Brief]
- [2]. De SY, et, al. SHP-2 specific deletion in macrophages accelerates pathological cardiac hypertrophy through promoting IRE1α-XBP1s pathway regulated by IL-6 secretion. Research Article. 2022 May 3.
