Histone Methyltransferase Ligand

5-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide is a drug intermediate for synthesis of various active compounds.

PRMT5 ligand 2 (Compound 38) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PRMT5 ligand 2 can be used for synthesis MS115 (HY-173561).

UNC0642-C3-COOH is a bivalent G9a/GLP ligand that can be used for the synthesis of PROTACs, such as MS8709 (HY-162362).

DOT1L ligand-1 is a DOT1L ligand. DOT1L ligand-1 can be used as a Ligands for Target Protein for PROTAC synthesis, such as MS2133 (HY-173422).

EZH2 ligand-1 (Compound E) is an EZH2 ligand that can be used for the synthesis of PORTAC.

EZH2 ligand-3, a EZH2 ligand, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). EZH2 ligand-3 can be used for the synthesis of PROTAC EZH2 Degrader-35 (HY-181392).

PRMT5 ligand 3 (Compound S19) is a PRMT5 ligand that can be used for the synthesis of PROTACs, such as RAPRMT5 (HY-181521).

PRMT5-IN-20 (P31 Claim 1) hydrochloride is a selective inhibitor of protein arginine methyltransferase 5 (PRMT5), and it can be used in cancer research.

DOT1L ligand-2 (Compound 52) is a DOT1L ligand. DOT1L ligand-2 acts as a Ligand for Target Protein for PROTAC, which is used to develop and design degraders of PROTAC DOT1L, such as DOT1L808 (HY-181789). DOT1L ligand-2 is applicable to research related to MLL-rearranged leukemia.

Thalidomide-4-O-C10-piperidine-NHBoc is an intermediate in the synthesis of G9a-targeting PROTAC, and serves as the E3 ligase ligand-linker conjugate moiety for PROTAC G9a degrader-1 (HY-187214).

PRMT1 ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate containing a PRMT1 ligand (HY-182297) and a PROTAC linker, which recruits E3 ligases. PRMT1 ligand-Linker Conjugate 1 can be used to synthesize PROTAC PRMT1 degrader-1 (HY-182275).

EZH2 ligand-5 is an EZH2 ligand. EZH2 ligand-5 serves as a ligand for the target protein in the synthesis of PROTAC EZH2 degraders, such as MS177 (HY-148333). EZH2 ligand-5 can be used in leukemia research.

G9a ligand-1 is a target protein ligand that targets G9a, and it can be used in PROTAC-related research, such as serving as the PROTAC target protein ligand for PROTAC G9a degrader-1 (HY-187214).

PRMT5 ligand 1 (compound 3) is the ligand for PRMT5 that can be used as target protein ligand for synthesis of PROTAC degrader MS4322 (HY-141877).

BI-9321-C10-acid is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for NSD3 (HY-114208) and a PROTAC linker (HY-114208). BI-9321-C10-acid can be used for synthesis of PROTAC NSD3 degrader-1 (HY-155816).