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Cat. No.: HY-187215

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G9a ligand-1

G9a ligand-1 is a target protein ligand that targets G9a, and it can be used in PROTAC-related research, such as serving as the PROTAC target protein ligand for PROTAC G9a degrader-1 (HY-187214).

For research use only. We do not sell to patients.

CAS No.: 2514847-74-4
Formula: C₁₆H₂₁ClN₄O₂
Molecular Weight:336.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

G9a ligand-1 Chemical Structure

CAS No.: 2514847-74-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

G9a

All Histone Methyltransferase Isoforms :

In Vitro

G9a ligand-1 (compound 4) serves as the PROTAC target protein ligand of PROTAC G9a degrader-1 (HY-187214), a selective and orally active G9a PROTAC degrader with a DC₅₀ of 1.29 μM. PROTAC G9a degrader-1 inhibits the NF-κB signaling pathway, suppresses cancer cell proliferation and migration, promotes apoptosis and cell cycle arrest, and reduces the expression level of H3K9me2. In in vivo models, PROTAC G9a degrader-1 alleviates skin inflammation, reduces epidermal hyperplasia, and decreases Ki67 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2514847-74-4
Molecular Weight 336.82
Formula C₁₆H₂₁ClN₄O₂
SMILES

ClC1=C2C=C(OC)C(OC)=CC2=NC(N3CCN(C)CCC3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu M, et al. Discovery of a potent PROTAC targeting G9a suppresses proliferation of triple-negative breast cancer cells and psoriasis-like keratinocytes. European journal of medicinal chemistry. 2026 Jul 08;318:119131. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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G9a ligand-1

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

G9a ligand-1 Related Classifications

HY-187215 Related Classifications