G9a ligand-1
G9a ligand-1 is a target protein ligand that targets G9a, and it can be used in PROTAC-related research, such as serving as the PROTAC target protein ligand for PROTAC G9a degrader-1 (HY-187214).
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- CAS No.: 2514847-74-4
- Formule: C16H21ClN4O2
- Masse moléculaire:336.82
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
G9a |
In Vitro
G9a ligand-1 (compound 4) serves as the PROTAC target protein ligand of PROTAC G9a degrader-1 (HY-187214), a selective and orally active G9a PROTAC degrader with a DC50 of 1.29 μM. PROTAC G9a degrader-1 inhibits the NF-κB signaling pathway, suppresses cancer cell proliferation and migration, promotes apoptosis and cell cycle arrest, and reduces the expression level of H3K9me2. In in vivo models, PROTAC G9a degrader-1 alleviates skin inflammation, reduces epidermal hyperplasia, and decreases Ki67 expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 2514847-74-4
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Masse moléculaire 336.82
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Formule C16H21ClN4O2
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SMILES
ClC1=C2C=C(OC)C(OC)=CC2=NC(N3CCN(C)CCC3)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
G9a ligand-1 Related Classifications
HY-187215 Related Classifications
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