Thalidomide-4-O-C10-piperidine-NHBoc
Thalidomide-4-O-C10-piperidine-NHBoc is an intermediate in the synthesis of G9a-targeting PROTAC, and serves as the E3 ligase ligand-linker conjugate moiety for PROTAC G9a degrader-1 (HY-187214).
For research use only. We do not sell to patients.
- Formula: C33H48N4O7
- Molecular Weight:612.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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G9a |
Thalidomide-4-O-C10-piperidine-NHBoc (compound 7d) serves as an intermediate in the development of PROTAC G9a degrader-1 (HY-187214), a selective and orally active G9a PROTAC degrader with a DC50 of 1.29 μM. PROTAC G9a degrader-1 inhibits the NF-κB signaling pathway, suppresses cancer cell proliferation and migration, promotes apoptosis and cell cycle arrest, and reduces the expression level of H3K9me2. In in vivo models, PROTAC G9a degrader-1 alleviates skin inflammation, reduces epidermal hyperplasia, and decreases Ki67 expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 612.76
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Formula C33H48N4O7
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCCCCCCCCCN4CCC(NC(OC(C)(C)C)=O)CC4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Thalidomide-4-O-C10-piperidine-NHBoc Related Classifications
HY-187216 Related Classifications
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