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3-Deazaneplanocin A

(Synonyms: DZNep; 3-Deazaneplanocin)
35 Cited Publications
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Based on 35 publication(s) in Google Scholar

3-Deazaneplanocin A (DZNep) is a potent histone methyltransferase EZH2 inhibitor. 3-Deazaneplanocin A is a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. 3-Deazaneplanocin A shows anti-orthopoxvirus activity.

For research use only. We do not sell to patients.

  • Purity: 99.80%
  • CAS No.: 102052-95-9
  • Formula: C12H14N4O3
  • Molecular Weight:262.26
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • 3-Deazaneplanocin A Chemical Structure
    3-Deazaneplanocin A Chemical Structure
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
  • Experimental Validation Results for 3-Deazaneplanocin A
CAS No.: 102052-95-9
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All Histone Methyltransferase Isoforms

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  • 3-Deazaneplanocin A Chemical Structure
    3-Deazaneplanocin A Chemical Structure
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  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: J Exp Med. 2026 Jan 5;223(1):e20250603. [Abstract]

    Customer Validation
     The levels of p-RIPK1(S166), CC8, CC3, and ADK were detected by Western blotting using DZNep (3-Deazaneplanocin A: 10 μM; 12 h).

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Jan 10;13(1):12. [Abstract]

    Customer Validation
     Immunoblot of MYCN in the presence of various EZH2 inhibitors. Kelly cells were respectively treated with 5 μM of 3-Deazaneplanocin A hydrochloride, GSK126 or EPZ6438 for 48 h before subjected to immunoblotting.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Jan 10;13(1):12. [Abstract]

    Customer Validation
     Proliferation of Kelly cells was measured upon administration of 5 μM of 3-Deazaneplanocin A hydrochloride (5 days), GSK126 or EPZ6438.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Jan 10;13(1):12. [Abstract]

    Customer Validation
     Proliferation of Kelly cells was measured upon 3-Deazaneplanocin A hydrochloride treatment (5 μM, 5 days) with or without ectopic expression of the MYCN T50A.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Jan 10;13(1):12. [Abstract]

    Customer Validation
     Kelly xenografts were subjected to 3-Deazaneplanocin A hydrochloride (0.75-6 mg/kg) or GSK126 treatments at the indicated doses. Images of subcutaneous tumors (n = 3 per group) under various treatments are shown.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Jan 10;13(1):12. [Abstract]

    Customer Validation
     Kaplan-Meier survival plot of tumor-bearing TH-MYCN+/+ mice treated with 3-Deazaneplanocin A hydrochloride (3 mg/kg) or GSK126 (50 mg/kg). Significant difference between the 3-Deazaneplanocin A hydrochloride-treated group versus control was determined by log-rank test.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Jan 10;13(1):12. [Abstract]

    Customer Validation
     Immunohistochemistry detection of Ezh2, MYCN, and H3K27me3 upon 3-Deazaneplanocin A hydrochloride (3 mg/kg) or GSK126 treatment.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Nat Commun. 2021 Feb 23;12(1):1237. [Abstract]

    Customer Validation
     BT-R cells were treated with the specified compound 3-Deazaneplanocin A (DZNEP: 5 μM) for 48 hours. Then, the expression level of JAK2 mRNA was determined by RT-PCR and normalized to the expression level in the vector-treated cells.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Oct 23;11(10):906. [Abstract]

    Customer Validation
     Western blot analysis of EZH2, ZIC4, H3K27me3, and β-actin in HepG2 without or with DZNep (10 μM) treatment for 72 h.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Sep 10;503(3):2061-2067. [Abstract]

    Customer Validation
     Western blot analysis of H3K27me3, bcatenin and RUNX2 protein accumulation in hDFSCs transfected by EZH2-siRNA and treated with DMSO or DZNep after 3 days of osteogenic induction.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: J Am Soc Nephrol. 2016 Jul;27(7):2021-34. [Abstract]

    Customer Validation
     Immunoblotting mouse podocytes for (A) EZH2 and (B) H3K27me3 under control conditions or after DZNep treatment for 48 hours. Initial immunoblotting experiments confirm the presence of EZH2 protein in cultured mouse podocytes and its depletion with DZNep (A) together with a concurrent reduction in H3K27me3 levels (B).

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: J Am Soc Nephrol. 2016 Jul;27(7):2021-34. [Abstract]

    Customer Validation
     MEF cells transfected or untransfected with siAdk were stimulated with Flag-TNFα (10 ng/ml) for 15 min, followed by pretreatment with DZNep (3-Deazaneplanocin A: 10 μM), 5-ITu (20 μM), or adenosine (1 mM) for 1 h. Anti-Flag antibody was used to immunoprecipitate complex I, and the levels of RIPK1 R606me2s in complex I or whole-cell lysates were determined by Western blotting.

  • 1/16

    3-Deazaneplanocin A purchased from MedChemExpress. Usage Cited in: J Am Soc Nephrol. 2016 Jul;27(7):2021-34. [Abstract]

    Customer Validation
     HEK293T cells were co-transfected with HA-tagged RIPK1-DD and Flag-tagged RIPK1-DD expression plasmids for 24 hours. Cells were then treated with DZNep (3-Deazaneplanocin A: 10 μM), siADK, or adenosine (1 mM). The interaction between Flag-tagged and HA-tagged proteins was detected by immunoprecipitation and Western blotting.

  • 3-Deazaneplanocin A