28097-03-2
28097-03-2
Chemical Structure
Chaetocin
- CAS No.: 28097-03-2
- Formula:C30H28N6O6S4
- Molecular Weight:696.84
InChIKey: PZPPOCZWRGNKIR-PNVYSBBASA-N
SMILES: O=C([C@@](N1C)(SS2)CO)N3[C@](NC4=CC=CC=C54)([H])[C@]5([C@@]6(C7=CC=CC=C7N8)[C@@]8([H])N(C9=O)[C@](C%10=O)(SS[C@]9(CO)N%10C)C6)C[C@]32C1=O
Biological Activity: Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Chaetocin | 99.22% | Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM. | ||||||||||||||||||||
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Chetomin | 95.3% | Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule. | ||||||||||||||||||||
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Leptosin J | Leptosin J is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin J inhibits Leukemia lymphocyte P388 in culture with an ED50 of 1.25 μg/mL. | |||||||||||||||||||||
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Leptosin I | Leptosin I is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin I inhibits Leukemia lymphocyte P388 in culture with an ED50 of 1.13 μg/mL. | |||||||||||||||||||||
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Hodgkinsine B | Hodgkinsine B is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine B has antiviral, antibacterial and antifungal activities. | |||||||||||||||||||||
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Hodgkinsine | Hodgkinsine is an opioid receptor agonist and NMDA receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities. | |||||||||||||||||||||
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Gypsetin | Gypsetin can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with an IC50 of 18 μM, and its action is competitive with oleoyl-COA substrate, Ki value is 5.5 μM. Gypsetin also inhibits Oleic acid from forming cholesterol esters with an IC50 of 0.65 μM. | |||||||||||||||||||||
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Cristatumin E | 96% | Cristatumin E (Eurocristatine) is a natural alkaloid. | ||||||||||||||||||||
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Chimonanthine | 99.15% | Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis. | ||||||||||||||||||||
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Amauromine | Amauromine is a peripheral selective cannabinoid receptor type 1 (CB1) receptor antagonist with Ki and Kb values of 178 nM and 66.6 nM, respectively. | |||||||||||||||||||||
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WIN-64821 | WIN-64821 is a secondary metabolite produced by Aspergillus species, and acts as a Neurokinin Receptor antagonist. The Ki values of WIN-64821 for NK1, NK2 and NK3 receptors are 0.24 (human astrocytoma cells), 0.26 (rat duodenum) and 15.2 (guinea pig forebrain) μM, respectively. WIN-64821 inhibits apamin-induced contraction of rat vas deferens, blocks substance P-induced contraction of guinea pig ileum and Ca2+ efflux in human astrocytoma cells. WIN-64821 is applicable to analgesic and anti-inflammatory research. | |||||||||||||||||||||
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