MMP-13 Inhibitor

MMP-13 Inhibitors (29):

Cat. No.	Product Name	Effect	Purity

HY-N1463

Luteolin 7-O-glucuronide	Inhibitor	99.80%
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-12170A

Prinomastat hydrochloride	Inhibitor	≥98.0%
Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively.

HY-107394

UK 356618	Inhibitor	98.91%
UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC₅₀ of 5.9 nM.

HY-N1454

Apigenin-7-glucuronide	Inhibitor	98.83%
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-148571

TP0597850	Inhibitor
TP0597850 is a selective inhibitor of MMP2 (IC₅₀=0.22 nM).

HY-128026

MMP-9/MMP-13 Inhibitor I	Inhibitor
MMP-9/MMP-13 Inhibitor I is a potent MMP-9 and MMP-13 inhibitor with IC₅₀s of both 0.9 nM.

HY-114091

PF-00356231 hydrochloride	Inhibitor	99.52%
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC₅₀=1.4 μM).

HY-125166

DB04760	Inhibitor	98.45%
DB04760 (compound 4) is a potent, highly selective, non-zinc-chelating MMP-13 inhibitor with an IC₅₀ of 8 nM.

HY-107428

PD-166793	Inhibitor	≥99.0%
PD-166793 is a potent, selective, orally active and wide‐broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC₅₀=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC₅₀=6.0, 7.2, and 7.9 μM, respectively).

HY-19485

XL-784	Inhibitor	98.13%
XL-784 is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1，MMP-2，MMP-3，MMP-8，MMP-9，MMP-13，respectively.

HY-107639

UK-370106	Inhibitor	≥99.0%
UK-370106 is a potent and highly selective MMP-3 (IC₅₀ of 23 nM) and MMP-12 (IC₅₀ of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8.

HY-19677

Cipemastat	Inhibitor	99.49%
Cipemastat is a potent, competitive inhibitor of human collagenases 1, 2 and 3 with K_is of 3.0, 4.4 and 3.4 nM, respectively.

HY-N2350

Cynaropicrin	Inhibitor
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively.

HY-124029

BI-4394	Inhibitor	99.91%
BI-4394 (MMP13-IN-3) is a potent, selective, and orally active MMP-13 inhibitor (IC₅₀=1 nM) for the potential treatment of osteoarthritis.

HY-122624

MMP13-IN-2	Inhibitor	99.85%
MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor.

HY-120793

CMC2.24	Inhibitor
CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway.

HY-12168

Tanomastat	Inhibitor	≥99.0%
Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group.

HY-117970

MMPI-1154	Inhibitor	99.87%
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC₅₀=6.6 μM) and can be used for the study of acute myocardial infarction.

HY-W011085

CP-471474	Inhibitor
CP-471474 is an orally active and pan MMP inhibitor, with IC₅₀ values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively.

HY-146218

MMP-9-IN-5	Inhibitor
MMP-9-IN-5 is a MMP-9 inhibitor (IC₅₀: 4.49 nM) that forms hydrogen bond with MMP-9.

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