MMP13-IN-7
MMP13-IN-7 is an orally active MMP-13 inhibitor with a Ki value of 1.5 nM. MMP13-IN-7 targets the zinc-dependent protease MMP-13 that cleaves type II collagen. MMP13-IN-7 reduces elevated type II collagen neoepitope levels and the severity of osteoarthritis-like joint lesions in a canine meniscectomy model. MMP13-IN-7 can be used for research on osteoarthritis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1112169-64-8
- 分子式: C21H24FN7O5
- 分子量:473.46
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
MMP13 |
体外実験
MMP13-IN-7 (Compound 43a) is highly selective against MMP-3 and a panel of matrix metalloproteinases, TACE, and aggrecanase. MMP13-IN-7 inhibits cytokine-induced generation of type II collagen neoepitope in human articular cartilage.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
化学情報
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CAS 番号 1112169-64-8
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分子量 473.46
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分子式 C21H24FN7O5
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SMILES
O=C(C1=NC(C)=NC(C2=NN(C[C@@H]3OC[C@@H](CO)OC3)N=N2)=C1)NCC4=CC=C(F)C(OC)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Ruminski PG, et al. Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis. J Med Chem. 2016 Jan 14;59(1):313-27. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MMP13-IN-7 関連分類
HY-11037 関連分類
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