2. Metabolic Enzyme/Protease
  3. MMP
  4. UK 356618

UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with MMP-3.

For research use only. We do not sell to patients.

UK 356618 Chemical Structure

UK 356618 Chemical Structure

CAS No. : 230961-08-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 396 In-stock
Solution
10 mM * 1 mL in DMSO USD 396 In-stock
Solid
1 mg USD 120 In-stock
5 mg USD 360 In-stock
10 mg USD 600 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

UK 356618 Related Antibodies

Top Publications Citing Use of Products

    UK 356618 purchased from MedChemExpress. Usage Cited in: J Bone Miner Res. 2022 Nov 12.  [Abstract]

    The TRAP staining exhibits a reduced number of osteoclasts in the coculturing system of BMSCs treated with the MMP3 inhibitor UK 356618 (UK) and Raw 264.7 cells in response to the mechanical force.

    View All MMP Isoform Specific Products:

    View All Isoforms
    MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with MMP-3[1].

    IC50 & Target[1][2]

    MMP-3

    5.9 nM (IC50)

    MMP-13

    73 nM (IC50)

    MMP-9

    0.84 μM (IC50)

    MMP-2

    1.79 μM (IC50)

    MMP-14

    1.9 μM (IC50)

    MMP-1

    51 μM (IC50)

    In Vitro

    Inhibition of MMP-3 and selectivity over MMP-2 was remarkably sensitive to the size of the substituent and is clearly optimal for a methyl group (UK 356618, compound 4j). UK 356618 is more widely profiled against other MMPs[1].
    MMP-13 is closely involved in IL-6 or TNF-α increasing tumor metastasis. MMP-13 deficiency abrogate TNF-α effect on lung cancer cell migration. UK 356618 treatment efficiently abolished the effect of TNF-α on cell migration in NCI-H446 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    UK 356618 Related Antibodies
    In Vivo

    UK 356618 (15 mg/kg; intravenous injection; for 24 h or 7 days; male Wistar rats) treatment at reperfusion significantly reduces MMP3 activity in the brain[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Hyperglycemic male Wistar rats injected with middle cerebral artery occlusion (MCAO)[3]
    Dosage: 15 mg/kg
    Administration: Intravenous injection; for 24 h or 7 days
    Result: Significantly reduced MMP3 activity in the brain.
    Molecular Weight

    557.72

    Formula

    C34H43N3O4
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CC1=C(C2=CC=CC=C2)C=CC(CCC[C@H](CC(NO)=O)C(N[C@@H](C(C)(C)C)C(N[C@@H](C3=CC=CC=C3)C)=O)=O)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (44.83 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7930 mL 8.9651 mL 17.9301 mL
    5 mM 0.3586 mL 1.7930 mL 3.5860 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    (per animal)

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    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 98.91%

    COA (250 KB) LCMS (269 KB) Elemental Analysis Report (107 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7930 mL 8.9651 mL 17.9301 mL 44.8254 mL
    5 mM 0.3586 mL 1.7930 mL 3.5860 mL 8.9651 mL
    10 mM 0.1793 mL 0.8965 mL 1.7930 mL 4.4825 mL
    15 mM 0.1195 mL 0.5977 mL 1.1953 mL 2.9884 mL
    20 mM 0.0897 mL 0.4483 mL 0.8965 mL 2.2413 mL
    25 mM 0.0717 mL 0.3586 mL 0.7172 mL 1.7930 mL
    30 mM 0.0598 mL 0.2988 mL 0.5977 mL 1.4942 mL
    40 mM 0.0448 mL 0.2241 mL 0.4483 mL 1.1206 mL
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    UK 356618 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    UK 356618230961-08-7UK356618UK-356618MMPMatrix metalloproteinasesReperfusionhyperglycemicTNF-αmigrationcellInhibitorinhibitorinhibit

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