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Results for "

hyperglycemic

" in MedChemExpress (MCE) Product Catalog:

21

Inhibitors & Agonists

10

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0020
    2,2'-Bipyridine

    		Biochemical Assay Reagents Infection Endocrinology
    2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .
    2,2'-Bipyridine
  • HY-N0807
    Swertiamarin

    		Others Metabolic Disease Cancer
    Swertiamarin, a secoiridoid glycoside found in genera of Enicostemma littorale, confers anti-hyperglycemic and anti-hyperlipidemic effects .
    Swertiamarin
  • HY-N0547
    Nomilin

    		Others Metabolic Disease
    Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .
    Nomilin
  • HY-N0472
    Geraniin
    2 Publications Verification

    		 TNF Receptor Metabolic Disease Inflammation/Immunology Cancer
    Geraniin is a TNF-α releasing inhibitor with numerous activities including anticancer, anti-inflammatory, and anti-hyperglycemic activities, with an IC50 of 43 μM.
    Geraniin
  • HY-146128
    Anti-hyperglycemic agent-1

    		Glucosidase Metabolic Disease
    Anti-hyperglycemic agent-1 (compound 10) is a potent α-Glucosidase inhibitor, with an IC50 of 0.53 μM. Anti-hyperglycemic agent-1 can be used for diabetes research .
    Anti-<em>hyperglycemic</em> agent-1
  • HY-133127A
    AR453588 hydrochloride

    		Glucokinase Metabolic Disease
    AR453588 hydrochloride is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 hydrochloride shows anti-hyperglycemic activity .
    AR453588 hydrochloride
  • HY-133127
    AR453588

    		Glucokinase Metabolic Disease
    AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 shows anti-hyperglycemic activity .
    AR453588
  • HY-N1185
    Tagitinin A

    Tagitinin A is a sesquiterpene with anti-hyperglycemic activity. Tagitinin A significantly inhibits glucose uptake in differentiated 3T3-L1 adipocytes .
    Tagitinin A
  • HY-N8018
    Leucosceptoside A

    		PKC Glucosidase Angiotensin-converting Enzyme (ACE) Neurological Disease Metabolic Disease
    Leucosceptoside A is a phenylethanoid glycoside with anti-hyperglycemic and anti-hypertensive activities. Leucosceptoside A shows inhibitory activity against α-glucosidase and PKCα (IC50 of 19.0 μM) .
    Leucosceptoside A
  • HY-110118
    Edaglitazone

    		PPAR
    Edaglitazone is a potent, selective and orally active PPARγ agonist, with EC50s of 35.6 nM and 1053 nM for PPARα and PPARγ, respectively. Edaglitazone displays antiplatelet, antidiabetic and anti-hyperglycemic activity .
    Edaglitazone
  • HY-B0225
    Methyldopa

    L-(-)-α-Methyldopa; MK-351

    		 Adrenergic Receptor Endogenous Metabolite Cardiovascular Disease Endocrinology
    Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .
    Methyldopa
  • HY-B0225A
    Methyldopa hydrochloride

    L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride

    		 Adrenergic Receptor Endogenous Metabolite Cardiovascular Disease Endocrinology
    Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .
    Methyldopa hydrochloride
  • HY-B0225B
    Methyldopa hydrate
    1 Publications Verification

    L-(-)-α-Methyldopa hydrate; MK-351 hydrate

    		 Adrenergic Receptor Endogenous Metabolite Cardiovascular Disease Endocrinology
    Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrate is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system .
    Methyldopa hydrate
  • HY-107394
    UK 356618
    4 Publications Verification

    		 MMP Inflammation/Immunology Cancer
    UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with MMP-3 .
    UK 356618
  • HY-N1390
    Syringaldehyde

    Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis . Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL . Anti-hyperglycemic and anti-inflammatory activities .
    Syringaldehyde
  • HY-N3078
    p-Hydroxyphenethyl trans-ferulate

    		Glucosidase Endocrinology
    p-Hydroxyphenethyl trans-ferulate has anti-hyperglycemic（yeast α-glucosidase，IC50 19.24 ± 1.73 µmol L-1）, antioxidant, and anti-inflammatory activities . p-Hydroxyphenethyl trans-ferulate shows inhibiting cancer preve
    p-Hydroxyphenethyl trans-ferulate
  • HY-156380
    α-Amylase/α-Glucosidase-IN-6

    		Amylases Glucosidase Metabolic Disease
    α-Amylase/α-Glucosidase-IN-6 (compound 5j) is a potent dual inhibitor of α-amylase and α-glucosidase, with IC50s of 17.0 and 40.1 µM, respectively. α-Amylase/α-Glucosidase-IN-6 exhibits anti-hyperglycemic activities .
    α-Amylase/α-Glucosidase-IN-6
  • HY-N12353
    Stevisalioside A

    		Phosphatase Metabolic Disease
    Stevisalioside A (Compound 2) can be isolated from Stevia serrata roots. Stevisalioside A is an orally active antidiabetic agent. Stevisaliosides A inhibits PTP1B (IC50: 526.8 μM). Stevisalioside A reduces blood glucose levels and the postprandial peak in oral glucose and insulin tolerance tests in Streptozotocin (HY-13753) induced hyperglycemic mice .
    Stevisalioside A
  • HY-131334
    AMPK activator 4

    		AMPK Metabolic Disease
    AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect .
    AMPK activator 4
  • HY-W011220
    Ciglitazone

    ADD-3878; U-63287

    		 PPAR Cardiovascular Disease Cancer
    Ciglitazone is a potent and selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells .
    Ciglitazone
  • HY-N6660
    Trisdecanoin

    Tricaprin; Glyceryl tridecanoate

    		 Endogenous Metabolite Androgen Receptor Metabolic Disease
    Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics .
    Trisdecanoin

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