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  4. 2,2'-Bipyridine

2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity.

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CAS No. : 366-18-7

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Based on 1 publication(s) in Google Scholar

Other Forms of 2,2'-Bipyridine:

2,2'-Bipyridine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 2,2'-Bipyridine

Microbiological Assay

    2,2'-Bipyridine purchased from MedChemExpress. Usage Cited in: J Photochem Photobiol B. 2024 Aug 30:259:113023.  [Abstract]

    Modulation of PAO1 sensitivity to 405 nm aBL in BHI medium with or without FeCl3 supplementation in the presence of the iron chelator 2,2'-Bipyridine (BIP) (500 μM).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    A2780 IC50
    44.8 μM
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant A2780/R human tumor cell lines
    		[PMID: 11931621]
    A2780 IC50
    > 20 μM
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive A2780/S human tumor cell lines
    		[PMID: 11931621]
    CCRF-CEM IC50
    51.9 μM
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-sensitive CCRF-CEM/S human tumor cell lines
    		[PMID: 11931621]
    CCRF-CEM IC50
    61.7 μM
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant CCRF-CEM/R human tumor cell lines
    		[PMID: 11931621]
    COS-7 EC50
    19 μM
    Compound: Bip
    Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    COS-7 EC50
    34 μM
    Compound: Bip
    Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    COS-7 EC50
    42 μM
    Compound: Bip
    Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
    		[PMID: 22957890]
    COS-7 IC50
    126 μM
    Compound: Bip
    Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    		[PMID: 22957890]
    COS-7 IC50
    84 μM
    Compound: Bip
    Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
    		[PMID: 22957890]
    HUVEC EC50
    10 μM
    Compound: 2,2'-bipyridine
    Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
    Antiproliferative activity against HUVEC after 30 hrs by [3H]-thymidine incorporation assay
    		[PMID: 23634668]
    SK-OV-3 IC50
    41.3 μM
    Compound: 2,2' bipy
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
    Inhibitory effect of Gold(III) complex, 2,2' bipy on growth of cisplatin-resistant SKOV3 human tumor cell lines
    		[PMID: 11931621]
    In Vivo

    2,2'-Bipyridine (40 mg/kg; s.c.; once) produces an initial hyperglycemia (an increase of 53.8 mg/100 mL at 2 hours) followed by a transient hypoglycemicphase at 24 hours and does not produce permanent diabetes[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Holtzman rats (6-8 weeks old)[2].
    Dosage: 40 mg/kg
    Administration: Subcutaneous injection; once.
    Result: Showed hyperglycemic activity.
    Molecular Weight

    156.19

    Formula

    C10H8N2
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    C1(C2=NC=CC=C2)=NC=CC=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Store at room temperature 3 years

    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (640.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.4025 mL 32.0123 mL 64.0246 mL
    5 mM 1.2805 mL 6.4025 mL 12.8049 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.95%

    SDS (480 KB)

    COA (250 KB) HNMR (228 KB) RP-HPLC (248 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 6.4025 mL 32.0123 mL 64.0246 mL 160.0615 mL
    5 mM 1.2805 mL 6.4025 mL 12.8049 mL 32.0123 mL
    10 mM 0.6402 mL 3.2012 mL 6.4025 mL 16.0061 mL
    15 mM 0.4268 mL 2.1342 mL 4.2683 mL 10.6708 mL
    20 mM 0.3201 mL 1.6006 mL 3.2012 mL 8.0031 mL
    25 mM 0.2561 mL 1.2805 mL 2.5610 mL 6.4025 mL
    30 mM 0.2134 mL 1.0671 mL 2.1342 mL 5.3354 mL
    40 mM 0.1601 mL 0.8003 mL 1.6006 mL 4.0015 mL
    50 mM 0.1280 mL 0.6402 mL 1.2805 mL 3.2012 mL
    60 mM 0.1067 mL 0.5335 mL 1.0671 mL 2.6677 mL
    80 mM 0.0800 mL 0.4002 mL 0.8003 mL 2.0008 mL
    100 mM 0.0640 mL 0.3201 mL 0.6402 mL 1.6006 mL
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    2,2'-Bipyridine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    2,2'-Bipyridine366-18-7MOFsMetal-Organic FrameworksmolecularscaffoldcaerulomycinscollismycinschelatingligandshyperglycemicInhibitorinhibitorinhibit

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