1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. Adrenergic Receptor
    Endogenous Metabolite
  3. Methyldopa

Methyldopa  (Synonyms: L-(-)-α-Methyldopa; MK-351)

Cat. No.: HY-B0225
Handling Instructions

Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a prodrug and is metabolized (α-Methylepinephrine) in the central nervous system.

For research use only. We do not sell to patients.

Methyldopa Chemical Structure

Methyldopa Chemical Structure

CAS No. : 555-30-6

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1 Publications Citing Use of MCE Methyldopa

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a prodrug and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

IC50 & Target

α adrenergic receptor

 

In Vivo

Methyldopa (L-(-)-α-Methyldopa; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 60-day-old male rats[2]
Dosage: 200 mg/kg
Administration: I.p.
Result: Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.
Clinical Trial
Molecular Weight

211.21

Formula

C10H13NO4

CAS No.
SMILES

OC1=C(O)C=CC(C[[email protected]@](C)(C(O)=O)N)=C1

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Methyldopa
Cat. No.:
HY-B0225
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