1. GPCR/G Protein
  2. Adrenergic Receptor

L-(-)-α-Methyldopa (Synonyms: MK-351; Methyldopa)

Cat. No.: HY-B0225
Handling Instructions

Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.

For research use only. We do not sell to patients.

L-(-)-α-Methyldopa Chemical Structure

L-(-)-α-Methyldopa Chemical Structure

CAS No. : 555-30-6

Size Price Stock
1 g USD 60 Get quote

* Please select Quantity before adding items.

Other In-stock Forms of L-(-)-α-Methyldopa:

Other Forms of L-(-)-α-Methyldopa:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Target: alpha-adrenergic agonist Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (also known as pregnancy-induced hypertension (PIH)). Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, also known as aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine. Dopamine is a precursor for norepinephrine (noradrenaline) and subsequently epinephrine (adrenaline). This inhibition results in reduced dopaminergic and adrenergic neurotransmission in the peripheral nervous system. This effect may lower blood pressure and cause central nervous system effects such as depression, anxiety, apathy, anhedonia, and parkinsonism. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase (DBH). α-methylnorepinephrine is an agonist of presynaptic central nervous system α2-adrenergic receptors. Activation of these receptors in the brainstem appears to inhibit sympathetic nervous system output and lower blood pressure. This is also the mechanism of action of clonidine.

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7346 mL 23.6731 mL 47.3462 mL
5 mM 0.9469 mL 4.7346 mL 9.4692 mL
10 mM 0.4735 mL 2.3673 mL 4.7346 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

211.21

Formula

C₁₀H₁₃NO₄

CAS No.

555-30-6

SMILES

OC1=C(O)C=CC(C[[email protected]@](C)(C(O)=O)N)=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
L-(-)-α-Methyldopa
Cat. No.:
HY-B0225
Quantity:

L-(-)-α-Methyldopa

Cat. No.: HY-B0225