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Cat. No.: HY-B0225A

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Methyldopa hydrochloride

Name: Methyldopa hydrochloride
Brand: MedChemExpress
SKU: HY-B0225A
Availability: PreOrder

(Synonyms: L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride) hydrochloride, a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa hydrochloride is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system.

For research use only. We do not sell to patients.

CAS No.: 884-39-9
Formula: C₁₀H₁₄ClNO₄
Molecular Weight:247.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Methyldopa hydrochloride Chemical Structure

CAS No.: 884-39-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

α adrenergic receptor

All Adrenergic Receptor Isoforms :

All Endogenous Metabolite Isoforms :

In Vivo

Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrochloride; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

60-day-old male rats^[2]
Dosage:

200 mg/kg
Administration:

I.p.
Result:

Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.

Chemical Information

CAS No. 884-39-9
Molecular Weight 247.68
Formula C₁₀H₁₄ClNO₄
SMILES

OC1=C(O)C=CC(C[C@@](C)(C(O)=O)N)=C1.Cl
Synonyms

L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride
Structure Classification
- Alkaloids
- Other Alkaloids
- Phenols
- Polyphenols
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Clin Chem

Discovering Cross-Reactivity in Urine Drug Screening Immunoassays through Large-Scale Analysis of Electronic Health Records. [Abstract]

2019 Dec;65(12):1522-1531. PMID: 31578215
Cell Rep Methods

RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]

2023 Oct 23;3(10):100599. PMID: 37797618

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56. [Content Brief]

[2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Methyldopa hydrochloride

2 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References

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Methyldopa hydrochloride

Publications Citing Use of MedChemExpress (MCE) Methyldopa hydrochloride

All Adrenergic Receptor Isoforms

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

Methyldopa hydrochloride Related Classifications

HY-B0225A Related Classifications

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