1. Metabolic Enzyme/Protease
  2. MMP
  3. MMP13-IN-2

MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC50=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research.

For research use only. We do not sell to patients.

MMP13-IN-2 Chemical Structure

MMP13-IN-2 Chemical Structure

CAS No. : 935759-55-0

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Solid + Solvent
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 440 In-stock
Solid
5 mg USD 400 In-stock
10 mg USD 680 In-stock
25 mg USD 1350 In-stock
50 mg USD 2200 In-stock
100 mg USD 3400 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

MMP13-IN-2 is a potent, selective and orally active MMP-13 inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC50=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research[1].

IC50 & Target[1]

MMP-13

0.036 nM (IC50)

MMP-2

180 nM (IC50)

MMP-3

1100 nM (IC50)

In Vitro

In a bovine nasal cartilage (BNC) assay, the chondrocyte-mediated degradation of cartilage was studied using bovine nasal cartilage slices cultured for up to 14 days. MMP13-IN-2 (0.01-1 µM) is effective at preventing the IL-1/OSM induced in vitro degradation of BNC (-17.6%, 48.4% and 70.8% inhibition of cartilage degradation, respectively).[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MMP13-IN-2 (oral gavage; 1 mg/kg) shows the best combination of CYP3A4 inhibition risk and oral exposure at a dose of 1 mg/kg in rats and mice (F% = 33 and 38, respectively)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

506.51

Formula

C24H19FN6O4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(NC1=C2C(C3=CC=CC(F)=C3)=CS1)=NC2=O)NCC4=CC=CC(OCCOC5=NC=NN5)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (197.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9743 mL 9.8715 mL 19.7429 mL
5 mM 0.3949 mL 1.9743 mL 3.9486 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9743 mL 9.8715 mL 19.7429 mL 49.3574 mL
5 mM 0.3949 mL 1.9743 mL 3.9486 mL 9.8715 mL
10 mM 0.1974 mL 0.9871 mL 1.9743 mL 4.9357 mL
15 mM 0.1316 mL 0.6581 mL 1.3162 mL 3.2905 mL
20 mM 0.0987 mL 0.4936 mL 0.9871 mL 2.4679 mL
25 mM 0.0790 mL 0.3949 mL 0.7897 mL 1.9743 mL
30 mM 0.0658 mL 0.3290 mL 0.6581 mL 1.6452 mL
40 mM 0.0494 mL 0.2468 mL 0.4936 mL 1.2339 mL
50 mM 0.0395 mL 0.1974 mL 0.3949 mL 0.9871 mL
60 mM 0.0329 mL 0.1645 mL 0.3290 mL 0.8226 mL
80 mM 0.0247 mL 0.1234 mL 0.2468 mL 0.6170 mL
100 mM 0.0197 mL 0.0987 mL 0.1974 mL 0.4936 mL
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MMP13-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MMP13-IN-2
Cat. No.:
HY-122624
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