Tanomastat
Based on 1 Customer Validation
Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 179545-77-8
- Formula: C23H19ClO3S
- Molecular Weight:410.91
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MMP-2 11 nM (Ki) |
MMP-3 143 nM (Ki) |
MMP-9 301 nM (Ki) |
MMP-13 1470 nM (Ki) |
Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM), without affecting cell proliferation[2].
Tanomastat (BAY 12-9566) (1-00 µM; 5 days) inhibits tubule formation completely at 15-100 µM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six- to eight-week-old female BALB/c nude mice (bearing MDA-MB-435 cells)[3]
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Dosage:100 mg/kg
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Administration:p.o.; daily for a 7-week period
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Result:Inhibited local tumor regrowth by 58% without causing any toxic effect, and inhibited the number and volume of lung metastases by 57 and 88%, respectively.
Chemical Information
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CAS No. 179545-77-8
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Appearance Solid
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Molecular Weight 410.91
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Formula C23H19ClO3S
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Color White to off-white
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SMILES
ClC1=CC=C(C2=CC=C(C(C[C@H](CSC3=CC=CC=C3)C(O)=O)=O)C=C2)C=C1
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Synonyms
BAY 12-9566
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (60.84 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Leung D, et al. Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43(3):305-41. [Content Brief]
[2]. Gatto C, et al. BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity. Clin Cancer Res. 1999 Nov;5(11):3603-7. [Content Brief]
[3]. Nozaki S, et al. Activity of biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in a human breast cancerorthotopic model. Clin Exp Metastasis. 2003;20(5):407-12. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4336 mL | 12.1681 mL | 24.3362 mL | 60.8406 mL |
| 5 mM | 0.4867 mL | 2.4336 mL | 4.8672 mL | 12.1681 mL | |
| 10 mM | 0.2434 mL | 1.2168 mL | 2.4336 mL | 6.0841 mL | |
| 15 mM | 0.1622 mL | 0.8112 mL | 1.6224 mL | 4.0560 mL | |
| 20 mM | 0.1217 mL | 0.6084 mL | 1.2168 mL | 3.0420 mL | |
| 25 mM | 0.0973 mL | 0.4867 mL | 0.9734 mL | 2.4336 mL | |
| 30 mM | 0.0811 mL | 0.4056 mL | 0.8112 mL | 2.0280 mL | |
| 40 mM | 0.0608 mL | 0.3042 mL | 0.6084 mL | 1.5210 mL | |
| 50 mM | 0.0487 mL | 0.2434 mL | 0.4867 mL | 1.2168 mL | |
| 60 mM | 0.0406 mL | 0.2028 mL | 0.4056 mL | 1.0140 mL |
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