1. Metabolic Enzyme/Protease
  2. MMP
  3. Tanomastat

Tanomastat (Synonyms: BAY 12-9566)

Cat. No.: HY-12168 Purity: >99.0%
Handling Instructions

Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models.

For research use only. We do not sell to patients.

Tanomastat Chemical Structure

Tanomastat Chemical Structure

CAS No. : 179545-77-8

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Description

Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3].

IC50 & Target[1]

MMP-2

11 nM (Ki)

MMP-3

143 nM (Ki)

MMP-9

301 nM (Ki)

MMP-13

1470 nM (Ki)

In Vitro

Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM), without affecting cell proliferation[2].
Tanomastat (BAY 12-9566) (1-00 µM; 5 days) inhibits tubule formation completely at 15-100 µM[3].

In Vivo

Tanomastat (BAY 12-9566) (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth without causing any toxic effect, and inhibits the number and volume of lung metastases[3].

Animal Model: Six- to eight-week-old female BALB/c nude mice (bearing MDA-MB-435 cells)[3]
Dosage: 100 mg/kg
Administration: p.o.; daily for a 7-week period
Result: Inhibited local tumor regrowth by 58% without causing any toxic effect, and inhibited the number and volume of lung metastases by 57 and 88%, respectively.
Molecular Weight

410.91

Formula

C₂₃H₁₉ClO₃S

CAS No.

179545-77-8

SMILES

ClC1=CC=C(C2=CC=C(C(C[[email protected]](CSC3=CC=CC=C3)C(O)=O)=O)C=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

TanomastatBAY 12-9566MMPMatrix metalloproteinasesorallycarboxylinvasivemetastatictumorMDA-MB-435cellslungmetastasesInhibitorinhibitorinhibit

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Tanomastat
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