1. MAPK/ERK Pathway
    Stem Cell/Wnt
    Immunology/Inflammation
    NF-κB
  2. ERK
    PGE synthase
    COX
    NF-κB
  3. Cafestol

Cafestol 

Cat. No.: HY-N6257
Handling Instructions

Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects.

For research use only. We do not sell to patients.

Cafestol Chemical Structure

Cafestol Chemical Structure

CAS No. : 469-83-0

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Description

Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1].

IC50 & Target[1]

ERK

 

COX-2

 

NF-κB

 

Molecular Weight

316.43

Formula

C₂₀H₂₈O₃

CAS No.

469-83-0

SMILES
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Cafestol
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HY-N6257
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