469-83-0
469-83-0
Chemical Structure
Cafestol
- CAS No.: 469-83-0
- Formula:C20H28O3
- Molecular Weight:316.43
IUPAC Name: (3bS,5aS,7R,8R,10aR,10bS)-7-(hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol
InChIKey: DNJVYWXIDISQRD-HWUKTEKMSA-N
SMILES: C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C5=C(OC=C5)CC2)C[C@@]([C@](CO)(O)C4)([H])CC3
Biological Activity: Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer[1][2][3][4].
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Cafestol | 99.20% | Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer. | ||||||||||||||||||||
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Cafestol (Standard) | ≥98% | Cafestol (Standard) is the analytical standard of Cafestol. This product is intended for research and analytical applications. Cafestol is an orally active diterpenoid and an inhibitor of ERK2. Cafestol has elevated blood lipids, anti-inflammatory, anti-angiogenic and anti-diabetic activities. In addition, Cafestol induces tumor cell apoptosis and autophagy, which can be used in the study of cancer. | ||||||||||||||||||||
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16-O-Methylcafestol | 99.61% | 16-O-Methylcafestol is a derivative of cafestol that can be isolated from green coffee beans. | ||||||||||||||||||||
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16-Oxokahweol | 16-Oxokahweol, a Kahweol (HY-N6258) derivative, is a glutathione S-transferase inducer. | |||||||||||||||||||||
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Cafestol palmitate | Cafestol palmitate is an orally active diterpene ester. Cafestol palmitate can be isolated from raw coffee beans. Cafestol palmitate enhances the activity of Glutathione S-transferase. Cafestol palmitate downregulates the expression of Akt and VEGFR2. Cafestol palmitate can be used in the research of inflammatory diseases and cardiovascular diseases. | |||||||||||||||||||||
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16-Oxocafestol | 98.0% | 16-Oxocafestol is a diterpene ketone derivative of Cafestol (HY-N6257). 16-Oxocafestol increases the levels of glutathione S-transferase (GST) and tissue sulfhydryl groups in the liver and small intestinal mucosa. | ||||||||||||||||||||
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Pterokaurane R | Pterokaurane R is a Diterpenoids product that can be isolated from the herbs of Pteris multifida. | |||||||||||||||||||||
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Caesaljapin | Caesaljapin (Compound 4) is a cassane-type diterpenoid that can be isolated from plants of the genus Caesalpinia (Fabaceae). | |||||||||||||||||||||
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Corymbol | Corymbol ((6β)-Kaurane-6,16,17-triol) is a Diterpenoids product that can be isolated from the herbs of Wedelia trilobata. | |||||||||||||||||||||
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ent-Kaurane-3α,16β,17-triol | ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells. | |||||||||||||||||||||
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Kahweol (Standard) | ≥98% | Kahweol (Standard) is the analytical standard of Kahweol. This product is intended for research and analytical applications. Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. | ||||||||||||||||||||
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Kauran-16,17-diol | 99.80% | Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages. | ||||||||||||||||||||
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References
- [1]. Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. [Content Brief]
- [2]. Wang S, et al. Antiangiogenic properties of cafestol, a coffee diterpene, in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2012 May 11;421(3):567-71. [Content Brief]
- [3]. Feng Y, et al. Cafestol inhibits colon cancer cell proliferation and tumor growth in xenograft mice by activating LKB1/AMPK/ULK1-dependent autophagy. J Nutr Biochem. 2024 Jul;129:109623. [Content Brief]
- [4]. Mellbye FB, et al. Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice. J Nat Prod. 2017 Aug 25;80(8):2353-2359. [Content Brief]
