2. Apoptosis
  3. Apoptosis
  4. ent-Kaurane-3α,16β,17-triol

ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells.

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ent-Kaurane-3α,16β,17-triol

ent-Kaurane-3α,16β,17-triol Estructura química

No. CAS : 130855-22-0

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ent-Kaurane-3α,16β,17-triol Related Antibodies

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Descripciòn

ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells[1].

In Vitro

ent-Kaurane-3α,16β,17-triol (Compound 3; 0-100 μM; 24 h) shows IC50 values of 45.5 and 29.84 µM on HepG2 and HCT116 cells, respectively[1].
ent-Kaurane-3α,16β,17-triol (20 and 30 μM; 24 h) inhibits HCT116 cell colony formation[1].
ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 48 h) induces cell cycle arrest in human colon cancer cells[1].
ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 72 h) induces cellular apoptosis in human colon cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ent-Kaurane-3α,16β,17-triol Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2, MDA-MB-231, SCG-7901, OVCAR3 and HCT116 cells
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Showed inhibitory effects with IC50s of 29.84, 45.5, >100, >100 and >100 μM against HCT116, HepG2, MDA-MB-231, SCG-7901 and OVCAR3 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: HCT116
Concentration: 30 and 40 µM
Incubation Time: 48 h
Result: Significantly increased the cell population at the G0/G1 phase in a dosedependent manner.

Apoptosis Analysis[1]

Cell Line: HCT116
Concentration: 30 and 40 µM
Incubation Time: 72 h
Result: Increased the percentage of both early and late apoptotic cells.

Western Blot Analysis[1]

Cell Line: HCT116
Concentration: 30 μM
Incubation Time: 72 h
Result: Increased the expression levels of cleaved PARP, p27 and p53, and decreased the expression levels of cyclin D1 and CDK2.
Peso molecular

322.48

Fòrmula

C20H34O3
No. CAS
SMILES

C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C)(C(CC2)O)C)C[C@](CC3)([H])[C@@](O)(C4)CO
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Pureza y Documentación
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ent-Kaurane-3α,16β,17-triol Related Classifications

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Keywords:

ent-Kaurane-3α,16β,17-triol130855-22-0ApoptosisHCT116PARPp27p53cyclin D1CDK2HepG2Inhibitorinhibitorinhibit

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Nombre del producto:
ent-Kaurane-3α,16β,17-triol
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HY-N3825
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