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Cat. No.: HY-N3825

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ent-Kaurane-3α,16β,17-triol

ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells.

For research use only. We do not sell to patients.

CAS No.: 130855-22-0
Formula: C₂₀H₃₄O₃
Molecular Weight:322.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

ent-Kaurane-3α,16β,17-triol Chemical Structure

CAS No.: 130855-22-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells^[1].

In Vitro

ent-Kaurane-3α,16β,17-triol (Compound 3; 0-100 μM; 24 h) shows IC₅₀ values of 45.5 and 29.84 µM on HepG2 and HCT116 cells, respectively^[1].
ent-Kaurane-3α,16β,17-triol (20 and 30 μM; 24 h) inhibits HCT116 cell colony formation^[1].
ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 48 h) induces cell cycle arrest in human colon cancer cells^[1].
ent-Kaurane-3α,16β,17-triol (30 and 40 µM; 72 h) induces cellular apoptosis in human colon cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepG2, MDA-MB-231, SCG-7901, OVCAR3 and HCT116 cells
Concentration:

0-100 μM
Incubation Time:

24 h
Result:

Showed inhibitory effects with IC₅₀s of 29.84, 45.5, >100, >100 and >100 μM against HCT116, HepG2, MDA-MB-231, SCG-7901 and OVCAR3 cells, respectively.

Cell Cycle Analysis^[1]

Cell Line:

HCT116
Concentration:

30 and 40 µM
Incubation Time:

48 h
Result:

Significantly increased the cell population at the G0/G1 phase in a dosedependent manner.

Apoptosis Analysis^[1]

Cell Line:

HCT116
Concentration:

30 and 40 µM
Incubation Time:

72 h
Result:

Increased the percentage of both early and late apoptotic cells.

Western Blot Analysis^[1]

Cell Line:

HCT116
Concentration:

30 μM
Incubation Time:

72 h
Result:

Increased the expression levels of cleaved PARP, p27 and p53, and decreased the expression levels of cyclin D1 and CDK2.

Chemical Information

CAS No. 130855-22-0
Molecular Weight 322.48
Formula C₂₀H₃₄O₃
SMILES

C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C(C)(C(CC2)O)C)C[C@](CC3)([H])[C@@](O)(C4)CO
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen X, et al. Identification of terpenoids from Rubus corchorifolius L. f. leaves and their anti-proliferative effects on human cancer cells. Food Funct. 2017 Mar 22;8(3):1052-1060. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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