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Cat. No.: HY-138164

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Cafestol palmitate

Cafestol palmitate is an orally active diterpene ester. Cafestol palmitate can be isolated from raw coffee beans. Cafestol palmitate enhances the activity of Glutathione S-transferase. Cafestol palmitate downregulates the expression of Akt and VEGFR2. Cafestol palmitate can be used in the research of inflammatory diseases and cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 81760-46-5
Formula: C₃₆H₅₈O₄
Molecular Weight:554.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Cafestol palmitate Chemical Structure

CAS No.: 81760-46-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

VEGFR2

All Akt Isoforms :

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC50	>10 μg/mL	Inhibition of cyclooxygenase-2 (COX-2) activity in LPS-induced RAW 264.7 mouse macrophages assessed via measuring PGE₂ levels in supernatants by enzyme immunoassay, with 2 h incubation of test samples post-COX-2 induction. Inhibition of cyclooxygenase-2 (COX-2) activity in LPS-induced RAW 264.7 mouse macrophages assessed via measuring PGE₂ levels in supernatants by enzyme immunoassay, with 2 h incubation of test samples post-COX-2 induction.	1934578X0800300103
RAW264.7	IC50	>50 μg/mL	Antiproliferative activity against RAW 264.7 mouse macrophages assessed as reduction in cell viability incubated for 48 hrs by XTT assay. Antiproliferative activity against RAW 264.7 mouse macrophages assessed as reduction in cell viability incubated for 48 hrs by XTT assay.	1934578X0800300103
HL-60	IC50	>50 μg/mL	Antiproliferative activity against HL-60 myelomonocytic cells assessed as reduction in cell viability by MTT assay. Antiproliferative activity against HL-60 myelomonocytic cells assessed as reduction in cell viability by MTT assay.	1934578X0800300103
HL-60	IC50	>62.5 μg/mL	Antiproliferative activity against HL-60 myelomonocytic cells assessed as reduction in cell viability with 10 min pre-incubation before PMA addition, 16 h total incubation with PMA, by XTT assay. Antiproliferative activity against HL-60 myelomonocytic cells assessed as reduction in cell viability with 10 min pre-incubation before PMA addition, 16 h total incubation with PMA, by XTT assay.	1934578X0800300103

In Vitro

Cafestol palmitate (50 μM) inhibits the proliferation and migration of human microvascular endothelial cells by down-regulating VEGFR2 and Akt expression^[2].
Cafestol palmitate (2 h) weakly inhibits COX-2 activity in LPS-induced RAW 264.7 mouse macrophages with an IC₅₀ >10 μg/mL and shows no cytotoxicity in this cell line^[3].
Cafestol palmitate (48 h) does not exhibit significant cytotoxicity in RAW 264.7 mouse macrophages, with a cell proliferation IC₅₀ >50 μg/mL^[3].
Cafestol palmitate does not exhibit significant cytotoxicity in HL-60 myelomonocytic cells, with a cell proliferation IC₅₀ >50 μg/mL^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:

RAW 264.7 mouse macrophages
Concentration:

Unclear
Incubation Time:

48 h
Result:

Showed no significant cytotoxicity, with a cell proliferation IC₅₀ value greater than 50 μg/mL.

In Vivo

Cafestol palmitate (2.5-5.0 mg/mouse; p.o.; single dose, once daily for 4 days) dose-dependently enhances glutathione S-transferase activity in the small bowel mucosa of healthy female ICR/Ha mice, reaching 3.9 times control levels with four daily oral doses of 5.0 mg/mouse^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR/Ha (female, 7 weeks of age)^[1]
Dosage:

2.5 mg/mouse (single dose, marginal activity); 2.5 mg/mouse (4 daily doses, 41% increase); 5.0 mg/mouse (4 daily doses, 3.9x control)
Administration:

p.o.; single dose (killed 28h later); once daily for 4 days (killed 24h after last dose)
Result:

Resulted in marginal GSH S-transferase activity in small bowel mucosa.
Increased small bowel mucosa GSH S-transferase activity by 41% relative to controls.
Increased small bowel mucosa GSH S-transferase activity to 3.9 times the control level.

Chemical Information

CAS No. 81760-46-5
Molecular Weight 554.84
Formula C₃₆H₅₈O₄
SMILES

C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])C5=C(OC=C5)CC2)C[C@](CC3)([H])[C@](O)(C4)COC(CCCCCCCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lam LK, et al. Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse. Cancer Res. 1982 Apr;42(4):1193-8. [Content Brief]

[2]. Ren Y, et al. Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties. International journal of molecular sciences. 2019 Aug 30;20(17):4238.

[3]. Muhammad I, et al. COX-2 inhibitory activity of cafestol and analogs from coffee beans[J]. Natural Product Communications, 2008, 3(1): 1934578X0800300103.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Cafestol palmitate

All Akt Isoforms

All VEGFR Isoforms