1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase
  3. Hydralazine hydrochloride

Hydralazine hydrochloride 

Cat. No.: HY-B0464 Purity: 99.63%
Handling Instructions

Hydralazine hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.

For research use only. We do not sell to patients.

Hydralazine hydrochloride Chemical Structure

Hydralazine hydrochloride Chemical Structure

CAS No. : 304-20-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Hydralazine hydrochloride

    Hydralazine hydrochloride purchased from MCE. Usage Cited in: Neurosci Bull. 2020 Oct;36(10):1158-1170.

    Western blots (left) and analysis (right) of cyto-Drp1, mito-Drp1, and T-Drp1 in different groups of mice. Hydralazine (acrolein scavenger) suppresses the translocation of Drp1 and alleviates the morphological disruption of mitochondria after ICH in mice.
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    Description

    Hydralazine hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent. Target: Others Hydralazine hydrochloride (apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance, thereby lowering blood pressure and decreasing afterload. However, this only has a short term effect on blood pressure, as the system will reset to the previous, high blood pressure necessary to maintain pressure in the kidney necessary for natriuresis. The long term effect of antihypertensive drugs comes from their effects on the pressure natriuresis curve. It belongs to the hydrazinophthalazine class of drugs [1]. Hydralazine hydrochloride may reduce blood pressure when compared to placebo in patients with primary hypertension, however this data is based on before and after studies, not RCTs. Furthermore, its effect on clinical outcomes remains uncertain [2].

    Clinical Trial
    Molecular Weight

    196.64

    Formula

    C₈H₉ClN₄

    CAS No.
    SMILES

    NNC1=NN=CC2=C1C=CC=C2.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 25 mg/mL (127.14 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.0854 mL 25.4272 mL 50.8544 mL
    5 mM 1.0171 mL 5.0854 mL 10.1709 mL
    10 mM 0.5085 mL 2.5427 mL 5.0854 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Keywords:

    HydralazineHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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    Product Name:
    Hydralazine hydrochloride
    Cat. No.:
    HY-B0464
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