2. Others Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Epigenetics
  3. Reference Standards PGE synthase NO Synthase Reactive Oxygen Species (ROS) DNA Methyltransferase COX
  4. Hydralazine hydrochloride (Standard)

Hydralazine hydrochloride (Standard) 

Cat. No.: HY-B0464R Purity: 98%
Handling Instructions Technical Support

Hydralazine (hydrochloride) (Standard) is the analytical standard of Hydralazine (hydrochloride). This product is intended for research and analytical applications. Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine hydrochloride reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine hydrochloride inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGEE2; meanwhile, Hydralazine hydrochloride scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine hydrochloride alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine hydrochloride directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine hydrochloride has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain.

For research use only. We do not sell to patients.

Hydralazine hydrochloride (Standard)

Hydralazine hydrochloride (Standard) Chemical Structure

CAS No. : 304-20-1

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10 mg Get quote 4 - 6 weeks 3-5 weeks 5 - 7 weeks 4-6 weeks
25 mg Get quote 4 - 6 weeks 3-5 weeks 5 - 7 weeks 4-6 weeks
50 mg Get quote 4 - 6 weeks 3-5 weeks 5 - 7 weeks 4-6 weeks
100 mg Get quote 4 - 6 weeks 3-5 weeks 5 - 7 weeks 4-6 weeks
200 mg   Get quote  
500 mg   Get quote  
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Information

Hydralazine (hydrochloride) (Standard) is the analytical standard of Hydralazine (hydrochloride). This product is intended for research and analytical applications. Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine hydrochloride reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine hydrochloride inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGEE2; meanwhile, Hydralazine hydrochloride scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine hydrochloride alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine hydrochloride directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine hydrochloride has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

196.64

Formula

C₈H₉ClN₄
CAS No.
SMILES

NNC1=NN=CC2=C1C=CC=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Hydralazine hydrochloride (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydralazine hydrochloride (Standard)304-20-1Reference StandardsPGE synthaseNO SynthaseReactive Oxygen Species (ROS)DNA MethyltransferaseCOXProstaglandin E synthaseNitric oxide synthasesNOSDNMTsDNA MTasesCyclooxygenaseJurkatCEM-6MOLT-4ATCC-CCL2Spinal cord injurySpontaneously hypertensiveInhibitorinhibitorinhibit

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