915019-65-7
915019-65-7
Chemical Structure
Dactolisib
Synonym(s): BEZ235; NVP-BEZ235
- CAS No.: 915019-65-7
- Formula:C30H23N5O
- Molecular Weight:469.54
IUPAC Name: 2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
InChIKey: JOGKUKXHTYWRGZ-UHFFFAOYSA-N
SMILES: CN(C1=C2C3=CC(C4=CC5=CC=CC=C5N=C4)=CC=C3N=C1)C(N2C6=CC=C(C=C6)C(C)(C#N)C)=O
Biological Activity: Dactolisib (BEZ235) is an orally active and dual pan-class I PI3K and mTOR kinase inhibitor with IC50s of 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR, respectively. Dactolisib (BEZ235) inhibits both mTORC1 and mTORC2.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dactolisib | 99.94% | Dactolisib (BEZ235) is an orally active and dual pan-class I PI3K and mTOR kinase inhibitor with IC50s of 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR, respectively. Dactolisib (BEZ235) inhibits both mTORC1 and mTORC2. | ||||||||||||||||||||
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NVP-BEZ 235-d3 | NVP-BEZ 235-d3 is the deuterium labeled NVP-BEZ 235. | |||||||||||||||||||||
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