2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. NVP-BBD130

NVP-BBD130 is a potent, stable, ATP-competitive and orally active dual PI3K and mTOR inhibitor. NVP-BBD130 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

NVP-BBD130 Chemical Structure

NVP-BBD130 Chemical Structure

CAS No. : 853910-61-9

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NVP-BBD130 Related Antibodies

Top Publications Citing Use of Products

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NVP-BBD130 is a potent, stable, ATP-competitive and orally active dual PI3K and mTOR inhibitor[1]. NVP-BBD130 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PI3K, mTOR[1]
In Vitro

NVP-BBD130 (1 μM; 72 h) blocks proliferation of melanoma cells, arrests cell cycle at G1 phase in A2058 cells but not C32 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NVP-BBD130 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Melanoma cells
Concentration: 1 μM
Incubation Time: 3 days
Result: Showed a long-term effect on melanoma cell proliferation.

Western Blot Analysis[1]

Cell Line: A2058 and C32 cells
Concentration: 1 μM
Incubation Time: 0, 0.5, 1, 2, 4, 8, 12, 24, 48 and 72 h
Result: Decreased phosphorylation of PKB/Akt, whereas the phosphorylation status of MAPK was not affected.
Down-regulated the expression of cyclin D1, induced p27Kip1 expression in A2058 cells.

Cell Cycle Analysis[1]

Cell Line: A2058 cells
Concentration: 1 μM
Incubation Time: 3 days
Result: Resulted in a complete arrest of most tumor cells in G1.
In Vivo

NVP-BBD130 (40 mg/kg; p.o.; daily for 2 weeks) efficiently attenuates tumor growth at primary and lymph node metastatic sites with no obvious toxicity, and is well tolerant in B16BL6 mouse melanoma model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL6 mice, syngeneic B16BL6 mouse melanoma model[1]
Dosage: 40 mg/kg
Administration: Oral administration, daily for 2 weeks
Result: Reduced primary tumor size, showed a significant reduction in the size of the cervical lymph node metastasis.
Molecular Weight

443.50

Formula

C28H21N5O
CAS No.
SMILES

N#CC(C)(C)C1=CC=C(N2C(N(C)C3=CN=C4C=CC(C#CC5=CC=CN=C5)=CC4=C32)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NVP-BBD130 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVP-BBD130853910-61-9PI3KmTORPhosphoinositide 3-kinaseMammalian target of RapamycinATP-competitiveorally activeanticancermelanoma cellsA2058Inhibitorinhibitorinhibit

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