PI3K-IN-37
Based on 1 Customer Validation
PI3K-IN-37 (Example 84.1) is a PI3K α/β/δ inhibitor with IC50s of 6, 8, 4 nM, respectively. PI3K-IN-37 can also inhibit mTOR (IC50=4 nM).
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1257547-40-2
- Formula: C25H26N6O2
- Molecular Weight:442.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kδ 4 nM (IC50) |
mTOR 4 nM (IC50) |
PI3Kα 6 nM (IC50) |
PI3Kβ 8 nM (IC50) |
PI3K-IN-37 (0.005-10 μM; 30 min) treatment inhibits PKB Ser473 phosphorylation in Rat1 cells[1].
PI3K-IN-37 (0.005-1 μM; 60 min) treatment inhibits S6 Ribosomal Protein phosphorylation Ser235/236 in TSC1 nult MEF cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat1 cells
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Concentration:0.005-10 μM
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Incubation Time:30 min
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Result:Inhibited Pl3-kinase isoforms alpha, beta or delta phosphorylation with the IC50s of <5 nM, 8 nM, and 18 nM, respectively.
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Cell Line:TSC1-/- MEF cells
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Concentration:0.005-1 μM
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Incubation Time:60 min
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Result:Inhibited S6 Ribosomal Protein phosphorylation (IC50=2 nM).
Chemical Information
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CAS No. 1257547-40-2
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Appearance Solid
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Molecular Weight 442.51
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Formula C25H26N6O2
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Color Light yellow to light brown
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SMILES
O=C1N(C2=C(N1C)C=NC3=CC=C(C4=CC(OC(C)C)=C(C)N=C4)C=C23)C5=CN(C)N=C5C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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