1382979-44-3
1382979-44-3
Chemical Structure
Paxalisib
Synonym(s): GDC-0084
- CAS No.: 1382979-44-3
- Formula:C18H22N8O2
- Molecular Weight:382.42
IUPAC Name: 5-(6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl)pyrimidin-2-amine
InChIKey: LGWACEZVCMBSKW-UHFFFAOYSA-N
SMILES: NC1=NC=C(C2=NC(N3CCOCC3)=C4N=C(C(C)(C)OCC5)N5C4=N2)C=N1
Biological Activity: Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Paxalisib | 99.51% | Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-150034PI3K-IN-38 -
Similarity Score 0.60
HY-124036DS-7423 -
Similarity Score 0.56
HY-16585VS-5584 -
Similarity Score 0.55
HY-10811GNE-493 -
Similarity Score 0.53
HY-150109APuzerinostat -
Similarity Score 0.53
HY-101776Desmethyl-VS-5584 -
Similarity Score 0.51
HY-150109Puzerinostat mesylate -
Similarity Score 0.50
HY-10812GNE-490 -
Similarity Score 0.49
HY-175734PI3Kδ-IN-26 -
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