1. PI3K/Akt/mTOR
  2. PI3K
    mTOR
  3. DS-7423

DS-7423 

Cat. No.: HY-124036
Handling Instructions

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity.

For research use only. We do not sell to patients.

DS-7423 Chemical Structure

DS-7423 Chemical Structure

CAS No. : 1222104-37-1

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Description

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].

In Vitro

DS-7423 increases TP53 expression, the level of p-TP53 on Ser-46, and induced apoptosisrelated TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1].
DS-7423 also inhibits other isoforms of class I PI3K (IC50 values: PI3Kβ = 1,143 nM; PI3Kγ = 249 nM; PI3Kδ = 262 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

520.51

Formula

C₂₂H₂₇F₃N₁₀O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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