Copy Link Print Information

PI3K/AKT-IN-1

15 Cited Publications
Customer Review

Based on 15 publication(s) in Google Scholar

PI3K/AKT-IN-1 is an effective PI3K/AKT dual inhibitor (IC50 of 6.99, 4.01 and 3.36 μM for PI3Kγ, PI3Kδ and AKT, respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis.

For research use only. We do not sell to patients.

  • Purity: 99.64%
  • CAS No.: 3033069-84-7
  • Formula: C23H23N5O4S
  • Molecular Weight:465.52
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • PI3K/AKT-IN-1 Chemical Structure
    PI3K/AKT-IN-1 Chemical Structure
  • Experimental Validation Results for PI3K/AKT-IN-1
  • Experimental Validation Results for PI3K/AKT-IN-1
  • Experimental Validation Results for PI3K/AKT-IN-1
  • Experimental Validation Results for PI3K/AKT-IN-1
  • Experimental Validation Results for PI3K/AKT-IN-1
  • Experimental Validation Results for PI3K/AKT-IN-1
  • Experimental Validation Results for PI3K/AKT-IN-1
CAS No.: 3033069-84-7
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) PI3K/AKT-IN-1

More
Customer Validation & Images
WBRT-PCRCell Migration/Invasion AssayOthersCell Imaging/Staining
  • WB
  • RT-PCR
  • Others
  • WB
  • Cell Imaging/Staining
  • Cell Migration/Invasion Assay
  • Cell Migration/Invasion Assay

All PI3K Isoforms

More

All Akt Isoforms

More
Keywords
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • PI3K/AKT-IN-1 Chemical Structure
    PI3K/AKT-IN-1 Chemical Structure
    1/16
  • 1/16

    PI3K/AKT-IN-1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 May 22;16(1):4779. [Abstract]

    Customer Validation
     We treated primary hepatocytes with the PI3K/AKT specific inhibitor PI3K/AKT-IN-1 (10 μM) and found that the inhibitory effect of NNMT/1-MNA on FOXO1 and ANGPT2 was partially reduced.

  • 1/16

    PI3K/AKT-IN-1 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2025 Dec;17(1):2449095. [Abstract]

    Customer Validation
     Amino acid shortage model (AAS) for placental BeWo cells was established by mixing basic and amino acid-free DMEM/F12 medium (7:1), and supplemented with/without SCFAs cocktail and/or PI3K/AKT-IN-1 for 24 h. Relative gene expressions of inflammatory cytokines.

  • 1/16

    PI3K/AKT-IN-1 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Nov 7;11(1):511. [Abstract]

    Customer Validation
     We performed Pxr overexpression in these cells by using the plasmid containing the full-length coding sequence of Mus musculus Nr1i2 (PNr1i2) or empty vector as negative control (PNC), and used PI3K/AKT-IN-1 (5 μM), a specific inhibitor of the PI3K/Akt pathway, to assess the pathway’s role in mediating Pxr function in BMSCs.

  • 1/16

    PI3K/AKT-IN-1 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Nov 7;11(1):511. [Abstract]

    Customer Validation
     Pxr overexpression significantly enhanced PI3K/Akt pathway activity in aged BMSCs, while treatment with the inhibitor PI3K/AKT-IN-1 (5 μM) suppressed this Pxr overexpression-induced activation of the PI3K/Akt pathway.

  • 1/16

    PI3K/AKT-IN-1 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2025 Nov 7;11(1):511. [Abstract]

    Customer Validation
     The promotional effect of Pxr overexpression on osteogenesis in aged BMSCs was significantly weakened by the addition of PI3K/AKT-IN-1 (5 μM).

  • 1/16

    PI3K/AKT-IN-1 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Apr;45(4):844-856. [Abstract]

    Customer Validation
     Wound healing assay were used to evaluate cell motility, respectively, in PANC-1 cell lines treated with TGF-β1 (5 ng/ml, 24 h) and a MAPK1/ERK2-MAPK3/ERK1 inhibitor (U0126), MAPK/p38 inhibitor (SB203580), MAPK/JNK inhibitor (SP600125), PI3K/AKT-IN-1 (HY-144806), RAC1 inhibitor and CDC42 inhibitor.

  • 1/16

    PI3K/AKT-IN-1 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Apr;45(4):844-856. [Abstract]

    Customer Validation
     Transwell invasion were used to evaluate cell invasion, respectively, in PANC-1 cell lines treated with TGF-β1 (5 ng/ml, 24 h) and a MAPK1/ERK2-MAPK3/ERK1 inhibitor (U0126), MAPK/p38 inhibitor (SB203580), MAPK/JNK inhibitor (SP600125), PI3K/AKT-IN-1 (HY-144806), RAC1 inhibitor and CDC42 inhibitor.

  • PI3K/AKT-IN-1