2. PI3K/Akt/mTOR
  3. PI3K
  4. PIK-124

PIK-124 is a thiazolidinone-based PI3Kγ-biased PI3K inhibitor, with an IC50 of 3 nM against PI3Kγ. PIK-124 exhibits cross-reactivity with PI3Kα (IC50 = 23 nM), PI3Kδ (IC50 = 340 nM), PI3KC2α (IC50 = 140 nM) and PI3KC2β (IC50 = 370 nM). PIK-124 is applicable to breast cancer-related research.

For research use only. We do not sell to patients.

PIK-124

PIK-124 Chemical Structure

CAS No. : 711025-68-2

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PIK-124 Related Antibodies

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Description

PIK-124 is a thiazolidinone-based PI3Kγ-biased PI3K inhibitor, with an IC50 of 3 nM against PI3Kγ. PIK-124 exhibits cross-reactivity with PI3Kα (IC50 = 23 nM), PI3Kδ (IC50 = 340 nM), PI3KC2α (IC50 = 140 nM) and PI3KC2β (IC50 = 370 nM). PIK-124 is applicable to breast cancer-related research[1][2].

IC50 & Target[1]

PI3Kγ

3 nM (IC50)

PI3Kα

23 nM (IC50)

PI3Kδ

340 nM (IC50)

PI3KC2α

140 nM (IC50)

PI3KC2β

370 nM (IC50)

In Vitro

PIK-124 shows weak inhibitory effect on p-Akt in PTEN-WT cells, but effectively inhibits PI3Kγ-enriched systems[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PIK-124 Related Antibodies
Molecular Weight

434.88

Formula

C19H12ClFN2O3S2
CAS No.
SMILES

O=C1NC(=S)SC1=CC2=CC=C3OCC(=O)N(C3=C2)CC4=CC=C(F)C(Cl)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PIK-124 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIK-124711025-68-2PIK124PIK 124PI3KPhosphoinositide 3-kinasePI3Kγmouse peritoneal inflammation modelPI3KC2αPI3KδE. coliprotein kinasesleukocyte infiltrationbreast cancerPI3KC2βPI3KαInhibitorinhibitorinhibit

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