2. PI3K/Akt/mTOR Apoptosis
  3. mTOR Apoptosis Caspase
  4. RMC-4745

RMC-4745 is a selective dual-site inhibitor of mTORC1, with a selectivity of 35 times for mTORC1 and mTORC2. RMC-4745 inhibits the proliferation of MCF-7 cells and upregulates Caspase-3/7 activity to induce cell apoptosis. RMC-4745 does not cause the upregulation of HER3 due to the inhibition of mTORC2. RMC-4745 can be used for the study of breast cancer.

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RMC-4745

RMC-4745 Chemical Structure

CAS No. : 2250059-80-2

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RMC-4745 Related Antibodies

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mTOR mTORC1 mTORC2

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

RMC-4745 is a selective dual-site inhibitor of mTORC1, with a selectivity of 35 times for mTORC1 and mTORC2. RMC-4745 inhibits the proliferation of MCF-7 cells and upregulates Caspase-3/7 activity to induce cell apoptosis. RMC-4745 does not cause the upregulation of HER3 due to the inhibition of mTORC2. RMC-4745 can be used for the study of breast cancer[1].

IC50 & Target[1]

mTORC1

 

Caspase-3

 

Caspase-7

 

Molecular Weight

1824.20

Formula

C94H142N12O24
CAS No.
SMILES

NC1=C2C(C3=CC4=CC(O)=CC=C4N3)=NN(C2=NC=N1)CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCN5C=C(N=N5)CCCCO[C@H]6[C@@H](C[C@@H](CC6)C[C@H]([C@@]7([H])OC([C@@]8([H])N(CCCC8)C(C([C@@]9(O[C@](CC[C@H]9C)([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@@H]([C@@H](/C(C)=C/[C@H](C(C7)=O)C)O)OC)=O)C)C)NC(OC)=O)O)=O)=O)=O)C)OC)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RMC-4745 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RMC-47452250059-80-2RMC4745RMC 4745mTORApoptosisCaspaseMammalian target of RapamycinBiS-35xmTORC1-selective inhibitorbi-steric inhibitorallostericorthosteric4EBP1 phosphorylationAKT phosphorylationselectivitybreast cancercell proliferationapoptosisfeedback inhibitionInhibitorinhibitorinhibit

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