Filanesib hydrochloride
Based on 7 publication(s) in Google Scholar
Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.
For research use only. We do not sell to patients.
- Purity: 99.99%
- CAS No.: 1385020-40-5
- Formula: C20H23ClF2N4O2S
- Molecular Weight:456.94
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Filanesib hydrochloride
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Apoptosis Analysis
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In Vivo Efficacy Study
All Kinesin Isoforms
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Biological Activity
IC50: 6 nM (KSP)[1].
Chemical Information
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CAS No. 1385020-40-5
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Appearance Solid
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Molecular Weight 456.94
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Formula C20H23ClF2N4O2S
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Color White to off-white
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SMILES
O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.[H]Cl
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Synonyms
ARRY-520 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Cell Discov
Single-cell profiling reveals molecular basis of malignant phenotypes and tumor microenvironments in small bowel adenocarcinomas. [Abstract]2022 Sep 14;8(1):92. PMID: 36104333
Filanesib hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Discov. 2022 Sep 14;8(1):92. [Abstract]
Filanesib (0-100 μM; 36 h) inhibited HUTU-80 cell survival in a dose-dependent manner.
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Cancer Lett
2021 May 28:506:1-10. PMID: 33652084
Filanesib hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]
Filanesib (0-10 nM; 48 h) showed antiproliferative effects in the benign meningioma cell line Ben-Men-1 and the anaplastic cell lines NCH93, IOMM-Lee, and KT21-MG cells.
Filanesib hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]
Filanesib (10 nM; 24, 48, 72 h) induced cell cycle arrest at G2/M-phase in Ben-Men-1, NCH93, IOMM-Lee, and KT21-MG cells.
Filanesib hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]
Filanesib (10 nM; 72 h) induced cell apoptosis in Ben-Men-1, NCH93, IOMM-Lee, and KT21-MG cells.
Filanesib hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]
Filanesib (10 mg/kg; i.p.; once every three days on five occasions) inhibited NCH93 tumor growth in NCH93 tumor-bearing mice.
Filanesib hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 May 28:506:1-10. [Abstract]
Filanesib (10 mg/kg; i.p.; once every three days on five occasions) showed a significant reduction of Ki-67-positive cells in tumor sections.
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NPJ Precis Oncol
Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma. [Abstract]2025 Apr 25;9(1):122. PMID: 40281281 -
Gene
2025 Jul 5:955:149458. PMID: 40187619 -
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Methods Mol Biol
2018:1711:351-398. PMID: 29344898
Solvent & Solubility
DMSO : 100 mg/mL (218.85 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. BZ Carter, et al. Inhibition of KSP by ARRY-520 Induces Cell Cycle Block and Cell Death via the Mitochondrial Pathway in AML Cells. [Content Brief]
[3]. Ki Hyung Kim, et al. KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells. J Transl Med. 2009; 7: 63. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.1885 mL | 10.9424 mL | 21.8847 mL | 54.7118 mL |
| 5 mM | 0.4377 mL | 2.1885 mL | 4.3769 mL | 10.9424 mL | |
| 10 mM | 0.2188 mL | 1.0942 mL | 2.1885 mL | 5.4712 mL | |
| 15 mM | 0.1459 mL | 0.7295 mL | 1.4590 mL | 3.6475 mL | |
| 20 mM | 0.1094 mL | 0.5471 mL | 1.0942 mL | 2.7356 mL | |
| 25 mM | 0.0875 mL | 0.4377 mL | 0.8754 mL | 2.1885 mL | |
| 30 mM | 0.0729 mL | 0.3647 mL | 0.7295 mL | 1.8237 mL | |
| 40 mM | 0.0547 mL | 0.2736 mL | 0.5471 mL | 1.3678 mL | |
| 50 mM | 0.0438 mL | 0.2188 mL | 0.4377 mL | 1.0942 mL | |
| 60 mM | 0.0365 mL | 0.1824 mL | 0.3647 mL | 0.9119 mL | |
| 80 mM | 0.0274 mL | 0.1368 mL | 0.2736 mL | 0.6839 mL | |
| 100 mM | 0.0219 mL | 0.1094 mL | 0.2188 mL | 0.5471 mL |
Filanesib hydrochloride Related Classifications
HY-15187C Related Classifications
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