2. Cell Cycle/DNA Damage Apoptosis Cytoskeleton
  3. Kinesin Apoptosis
  4. Filanesib hydrochloride

Filanesib hydrochloride  (Synonyms: ARRY-520 hydrochloride)

Cat. No.: HY-15187C Purity: 99.99%
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SDS
Handling Instructions Technical Support

Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity.

For research use only. We do not sell to patients.

Filanesib hydrochloride

Filanesib hydrochloride Chemical Structure

CAS No. : 1385020-40-5

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Based on 7 publication(s) in Google Scholar

Other Forms of Filanesib hydrochloride:

Filanesib hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Kinesin Isoform Specific Products:

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Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14 Kinesin-13

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  • Customer Review

Description

Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity[1][2][3].

IC50 & Target

IC50: 6 nM (KSP)[1].
Molecular Weight

456.94

Formula

C20H23ClF2N4O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (218.85 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1885 mL 10.9424 mL 21.8847 mL
5 mM 0.4377 mL 2.1885 mL 4.3769 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.99%

SDS (252 KB)

COA (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1885 mL 10.9424 mL 21.8847 mL 54.7118 mL
5 mM 0.4377 mL 2.1885 mL 4.3769 mL 10.9424 mL
10 mM 0.2188 mL 1.0942 mL 2.1885 mL 5.4712 mL
15 mM 0.1459 mL 0.7295 mL 1.4590 mL 3.6475 mL
20 mM 0.1094 mL 0.5471 mL 1.0942 mL 2.7356 mL
25 mM 0.0875 mL 0.4377 mL 0.8754 mL 2.1885 mL
30 mM 0.0729 mL 0.3647 mL 0.7295 mL 1.8237 mL
40 mM 0.0547 mL 0.2736 mL 0.5471 mL 1.3678 mL
50 mM 0.0438 mL 0.2188 mL 0.4377 mL 1.0942 mL
60 mM 0.0365 mL 0.1824 mL 0.3647 mL 0.9119 mL
80 mM 0.0274 mL 0.1368 mL 0.2736 mL 0.6839 mL
100 mM 0.0219 mL 0.1094 mL 0.2188 mL 0.5471 mL
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Filanesib hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Filanesib1385020-40-5ARRY-520ARRY520ARRY 520KinesinApoptosiskinesinspindleproteinanti-proliferativeAMLacutemyelocyticleukemiaInhibitorinhibitorinhibit

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