1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Kinesin
  3. AZ82

AZ82 

Cat. No.: HY-12241 Purity: 99.08%
Handling Instructions

AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.

For research use only. We do not sell to patients.

AZ82 Chemical Structure

AZ82 Chemical Structure

CAS No. : 1449578-65-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 197 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.

IC50 & Target[1][2]

HSET/KIFC1

300 nM (IC50)

HSET/KIFC1

43 nM (Ki)

In Vitro

AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa[1]. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes with an IC50 of 0.90 ± 0.09 μM for mant-ATP binding and 1.26 ± 0.51 μM for mant-ADP releasing[2].

Molecular Weight

560.63

Formula

C₂₈H₃₁F₃N₄O₃S

CAS No.

1449578-65-7

SMILES

O=C(C1=CC(CCC)=C(C)S1)N[[email protected]](CC2=CC=C(C3=CC=CC(OC(F)(F)F)=C3)N=C2)C(N[[email protected]]4CNCC4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (222.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7837 mL 8.9185 mL 17.8371 mL
5 mM 0.3567 mL 1.7837 mL 3.5674 mL
10 mM 0.1784 mL 0.8919 mL 1.7837 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.71 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.08%

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Keywords:

AZ82AZ 82AZ-82KinesinInhibitorinhibitorinhibit

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Product name:
AZ82
Cat. No.:
HY-12241
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