EGFR-IN-40
EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1466445-39-5
- Formula: C23H20N6O3
- Molecular Weight:428.44
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All EGFR Isoforms
More
Biological Activity
|
BTK 1.2 nM (IC50) |
EGFR 5.3 nM (IC50) |
ITK 46.1 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCC827 | IC50 |
25.9 nM
Compound: 3z
|
Antiproliferative activity against gefitinib-sensitive human HCC827 cells harboring EGFR E746 to A750 deletion after 72 hrs by MTS assay
Antiproliferative activity against gefitinib-sensitive human HCC827 cells harboring EGFR E746 to A750 deletion after 72 hrs by MTS assay
|
[PMID: 24053674] |
| NCI-H1975 | IC50 |
3518 nM
Compound: 3z
|
Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells expressing T790M/L858R mutation after 72 hrs by MTS assay
Antiproliferative activity against gefitinib-resistant human NCI-H1975 cells expressing T790M/L858R mutation after 72 hrs by MTS assay
|
[PMID: 24053674] |
Chemical Information
-
CAS No. 1466445-39-5
-
Molecular Weight 428.44
-
Formula C23H20N6O3
-
SMILES
C=CC(NC1=CC=CC(N2C(C(C)=NC3=CN=C(NC4=CC=C(OC)C=C4)N=C23)=O)=C1)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-IN-40 Related Classifications
HY-143901 Related Classifications
Powered by Bioz