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Cat. No.: HY-146671

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ITK inhibitor 5

ITK inhibitor 5 (compound 27) is a potent and selective ITK inhibitor with IC₅₀s of 5.6, 25 nM for ITK, BTK, respectively.

For research use only. We do not sell to patients.

CAS No.: 2404603-41-2
Formula: C₂₁H₁₈F₂N₄O₂
Molecular Weight:396.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

ITK inhibitor 5 Chemical Structure

CAS No.: 2404603-41-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

ITK inhibitor 5 (compound 27) is a potent and selective ITK inhibitor with IC₅₀s of 5.6, 25 nM for ITK, BTK, respectively^[1].

Chemical Information

CAS No. 2404603-41-2
Molecular Weight 396.39
Formula C₂₁H₁₈F₂N₄O₂
SMILES

C=CC(NCCOC1=C2C=C(NC2=CC=C1)C3=NNC4=C3C=CC(C(F)F)=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang X, et al. Design, synthesis and structure-activity relationship of indolylindazoles as potent and selective covalent inhibitors of interleukin-2 inducible T-cell kinase (ITK). Eur J Med Chem. 2020 Feb 1;187:111918. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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