ITK antagonist
ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM.
For research use only. We do not sell to patients.
- CAS No.: 1149753-56-9
- Formula: C26H34N6O2S
- Molecular Weight:494.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| T-cell | IC50 |
20 nM
Compound: 10n
|
Inhibition of anti-CD3 and anti-CD28 monoclonal antibody-stimulated IL2 secretion in human CD4+ T cells
Inhibition of anti-CD3 and anti-CD28 monoclonal antibody-stimulated IL2 secretion in human CD4+ T cells
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[PMID: 19246196] |
Chemical Information
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CAS No. 1149753-56-9
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Molecular Weight 494.65
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Formula C26H34N6O2S
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SMILES
CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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