1. Protein Tyrosine Kinase/RTK
  2. Itk
  3. ITK inhibitor 6

ITK inhibitor 6 

Cat. No.: HY-146672
Handling Instructions

ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities.

For research use only. We do not sell to patients.

ITK inhibitor 6 Chemical Structure

ITK inhibitor 6 Chemical Structure

CAS No. : 2404604-06-2

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Description

ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities[1].

IC50 & Target

IC50: 4 nM (ITK); 133 nM (BTK), 320 nM (JAK3), 2360 nM (EGFR), 155 nM (LCK)[1]

In Vitro

ITK inhibitor 6 (compound 43) shows antiproliferative activities with GI50s of 5.1, 3.7, 3.4, 5.4, 19 µM for Jurkat, Molt-4, CCRF-CEM, H9, HEK 293 T cells, respectively[1].
ITK inhibitor 6 docks into the ATP-binding site of ITK and BTK[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

486.51

Formula

C28H24F2N4O2

CAS No.
SMILES

C=CC(NCCOC1=C2C=C(NC2=CC(CC3=CC=CC=C3)=C1)C4=NNC5=C4C=CC(C(F)F)=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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ITK inhibitor 6
Cat. No.:
HY-146672
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