2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. Efruxifermin

Efruxifermin  (Synonyms: AKR-001; AMG-876)

Cat. No.: HY-P99930 Purity: 98.58%
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Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis.

For research use only. We do not sell to patients.

CAS No. : 2375240-92-7

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Customer Review

Based on 2 publication(s) in Google Scholar

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Efruxifermin Related Antibodies

Top Publications Citing Use of Products
IF
In Vivo Efficacy Study
Histological Imaging/Staining
RT-PCR
WB

    Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3.  [Abstract]

    Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). Measurement of LVEF in the indicated groups.

    Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3.  [Abstract]

    Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). Representative image of HE staining.

    Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3.  [Abstract]

    Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). ANP and BNP mRNA levels in the indicated group.

    Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3.  [Abstract]

    Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). ANP and BNP protein levels in the indicated group.

    Efruxifermin purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 Aug 5:8:0815.  [Abstract]

    Efruxifermin (5 mg/kg; subcutaneous injection). The expression of SMA and OPN in SMA-positive cells in neointimal areas was determined by immunofluorescence staining.

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    • Purity & Documentation

    • References

    • Customer Review

    Description

    Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis[1].

    IC50 & Target

    FGFR1

     

    In Vivo

    Efruxifermin (0-100 mg/kg, SC, Once weekly, for 4 or 26 weeks) reduces body weight gain of Sprague Dawley rats in a dose-dependent manner[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male and female Sprague Dawley rats[1]
    Dosage: 0, 1, 10, 30, 100 mg/kg
    Administration: Subcutaneous injection, Once weekly, for 4 or 26 weeks
    Result: Significantly reduced body weight gain after 4 and 26 weeks, despite increasing food intake. Markers of sympathetic activation, urinary corticosterone and ratio of adrenal-to-body weight were unchanged.
    Clinical Trial
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    91.863 kDa

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Efruxifermin]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • IGHG1 Fc (Fragment constant)-[FGF21 (fibroblast growth factor 21)]2
    Purity & Documentation

    Purity: 98.58%

    SDS (251 KB)

    COA (232 KB) SDS-PAGE (88 KB) SEC-HPLC (150 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Efruxifermin Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Efruxifermin2375240-92-7AKR-001 AMG-876AKR001AKR 001AMG876AMG 876AMG-876FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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