1. Recombinant Proteins
  2. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  3. TGF-beta Superfamily Receptor Serine/Threonine Kinases Serine/Threonine Kinase Proteins
  4. TGF-beta Receptor TGF-beta Receptor 2
  5. TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc)

TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc)

Cat. No.: HY-P73430
COA Handling Instructions

TGFBR2 is a transmembrane kinase that forms the TGF-β receptor complex with TGFBR1 and regulates various processes. Upon binding to cytokines, this complex activates TGFBR2, initiating SMAD-dependent signaling through phosphorylation of TGFBR1, SMAD2, and SMAD4. TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is the recombinant rat-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is 166 a.a., with molecular weight of ~54 kDa.

For research use only. We do not sell to patients.

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Description

TGFBR2 is a transmembrane kinase that forms the TGF-β receptor complex with TGFBR1 and regulates various processes. Upon binding to cytokines, this complex activates TGFBR2, initiating SMAD-dependent signaling through phosphorylation of TGFBR1, SMAD2, and SMAD4. TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is the recombinant rat-derived TGFBR2/TGF-beta RII protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) is 166 a.a., with molecular weight of ~54 kDa.

Background

TGFBR2, a transmembrane serine/threonine kinase, partners with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, to form the specific receptor for TGF-beta cytokines, including TGFB1, TGFB2, and TGFB3. This receptor complex plays a pivotal role in transducing signals from the cell surface to the cytoplasm, thereby regulating diverse physiological and pathological processes. These include inducing cell cycle arrest in epithelial and hematopoietic cells, controlling mesenchymal cell proliferation and differentiation, influencing wound healing, extracellular matrix production, immunosuppression, and participating in carcinogenesis. The assembly of the receptor complex, comprising two TGFBR1 and two TGFBR2 molecules symmetrically bound to the cytokine dimer, leads to the constitutive activation of TGFBR2 and subsequent phosphorylation and activation of TGFBR1. Activated TGFBR1 then phosphorylates SMAD2, which dissociates from the receptor and forms a complex with SMAD4. This SMAD2-SMAD4 complex translocates to the nucleus, modulating the transcription of TGF-beta-regulated genes, thereby initiating the canonical SMAD-dependent TGF-beta signaling cascade. Additionally, TGFBR2 is involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Biological Activity

Measured by its ability to bind canine TGFB1-His in a functional ELISA.

Species

Rat

Source

HEK293

Tag

C-hFc

Accession

P38438 (M1-Q166)

Gene ID
Molecular Construction
N-term
TGFBR2 (M1-Q166)
Accession # P38438
hFc
C-term
Synonyms
TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II
Molecular Weight

Approximately 54 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE

Appearance

Solution.

Formulation

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc)
Cat. No.:
HY-P73430
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