2. Gene
  3. Tgfbr2 - transforming growth factor, beta receptor 2 Gene

Tgfbr2 - transforming growth factor, beta receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tgfbr2T; TGF-beta 2

Gene ID: 81810 | Gene type: protein coding

About Tgfbr2

Primary_assembly 8: 115,794,537-115,883,228 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 263 orthologues, 11 paralogues and is associated with 60 phenotypes. Biased expression in Lung (RPKM 782.6), Adrenal (RPKM 511.9) and 8 other tissues.

Summary

Enables mitogen-activated protein kinase kinase kinase binding activity and transforming growth factor beta receptor activity, type II. Involved in several processes, including animal organ development; negative regulation of cardiac muscle cell proliferation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in caveola; cell surface; and cytosol. Is integral component of plasma membrane. Used to study membranoproliferative glomerulonephritis. Biomarker of artery disease (multiple); hepatobiliary system Cancer (multiple); kidney disease; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system Cancer (multiple); hereditary nonpolyposis colorectal Cancer type 6; and pancreatic Cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgfbr2 Products(1)

mRNA Protein Name
NM_031132.4 NP_112394.4 TGF-beta receptor type-2 precursor

Tgfbr2 Protein Structure

ecTbetaR2

ecTbetaR2: pfam08917 (73 - 176)

STKc_TGFbR2_like

STKc_TGFbR2_like: cd14055 (272 - 566)

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  • 592 a.a.
Protein Preferred Names Protein Names

TGF-beta receptor type-2

TGF-beta receptor type II

TGF-beta type II receptor

TGFR-2

tbetaR-II

transforming growth factor beta receptor type II

transforming growth factor, beta receptor II

transforming growth factor, beta receptor IIT

transforming growth factor-b type II receptor

transforming growth factor-beta type II receptor

Recombinant Tgfbr2 Proteins

Cat. No. Product Name Accession Purity
HY-P73430 TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc) P38438 (M1-Q166) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100115 TA-02 Inhibitor 99.57% Unkown
HY-137506 XST-14 99.69% Unkown
HY-RS14447 TGFBR2 Human Pre-designed siRNA Set A / Unkown
HY-RS14448 Tgfbr2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14449 Tgfbr2 Rat Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99963 Sudubrilimab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfbr2 NCBI NCBI:7048
Mus musculus Tgfbr2 NCBI NCBI:21813
Macaca mulatta Tgfbr2 NCBI NCBI:703088