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Tgfbr2 - transforming growth factor, beta receptor 2 Gene

Also Known as Tgfbr2T; TGF-beta 2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81810

About Tgfbr2

Primary_assembly 8: 115,794,537-115,883,228 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 263 orthologues, 11 paralogues and is associated with 60 phenotypes. Biased expression in Lung (RPKM 782.6), Adrenal (RPKM 511.9) and 8 other tissues.

Summary

Enables mitogen-activated protein kinase kinase kinase binding activity and transforming growth factor beta receptor activity, type II. Involved in several processes, including animal organ development; negative regulation of cardiac muscle cell proliferation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in caveola; cell surface; and cytosol. Is integral component of plasma membrane. Used to study membranoproliferative glomerulonephritis. Biomarker of artery disease (multiple); hepatobiliary system Cancer (multiple); kidney disease; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system Cancer (multiple); hereditary nonpolyposis colorectal Cancer type 6; and pancreatic Cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgfbr2 Products (1)

mRNA	Protein	Name
NM_031132.4	NP_112394.4	TGF-beta receptor type-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	16360132	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8106553	RGD
enables transforming growth factor beta receptor activity, type II	IMP IMP: Inferred from mutant phenotype	18684975	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	10767079	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	9699514	RGD
involved in cellular response to acetaldehyde	IEP IEP: Inferred from expression pattern	12223100	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	12815632	RGD
involved in embryo implantation	IEP IEP: Inferred from expression pattern	16426643	RGD
involved in lung development	IEP IEP: Inferred from expression pattern	7573476	RGD
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	15537505	RGD
involved in negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	15961557	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15958511	RGD
involved in positive regulation of skeletal muscle tissue regeneration	IEP IEP: Inferred from expression pattern	10672325	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	11178962	RGD
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	14729511	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	8759618	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	11178962	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18760335	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	10432381	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	11675406	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16009107	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	9144876	RGD
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18684975	RGD
involved in vasculogenesis	IEP IEP: Inferred from expression pattern	9507219	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	17878231	RGD
located in cell surface	IDA IDA: Inferred from direct assay	14729511	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	17878231	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tgfbr2 Protein Structure

ecTbetaR2

STKc_TGFbR2_like

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592 a.a.

Protein Preferred Names	Protein Names
TGF-beta receptor type-2	TGF-beta receptor type II TGF-beta type II receptor TGFR-2 tbetaR-II transforming growth factor beta receptor type II transforming growth factor, beta receptor II transforming growth factor, beta receptor IIT transforming growth factor-b type II receptor transforming growth factor-beta type II receptor

Recombinant Tgfbr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73430	TGFBR2/TGF-beta RII Protein, Rat (HEK293, Fc)	P38438 (I24-Q166)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100115	TA-02	Inhibitor	99.44%	Unkown
HY-137506	XST-14		99.26%	Unkown
HY-RS14447	TGFBR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14448	Tgfbr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14449	Tgfbr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-137063	(+)-ITD-1		/	Unkown
HY-174530	Human TGFBR2 mRNA		/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99963	Sudubrilimab	Inhibitor	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfbr2	NCBI	NCBI:7048
Mus musculus	Tgfbr2	NCBI	NCBI:21813
Macaca mulatta	Tgfbr2	NCBI	NCBI:703088