1. MAPK/ERK Pathway
    Autophagy
  2. p38 MAPK
    Autophagy
  3. TA-02

TA-02 

Cat. No.: HY-100115 Purity: 99.30%
Handling Instructions

TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295).

For research use only. We do not sell to patients.

TA-02 Chemical Structure

TA-02 Chemical Structure

CAS No. : 1784751-19-4

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10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
1 mg USD 50 In-stock
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5 mg USD 120 In-stock
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10 mg USD 200 In-stock
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50 mg USD 600 In-stock
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100 mg USD 800 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TA-02, an analog of SB 203580 (HY-10256), is a p38 MAPK inhibitor with an IC50 of 20 nM. TA-02 especially inhibits TGFBR-2. TA-02 exhibits similar cardiogenic properties as SB 203580 and SB 202190 (HY-10295)[1].

In Vitro

TA-02 (5 μM) inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis. TA-02 at 5 μM concentration induces cardiogenesis, but also increases ATF-2 phosphorylation and MEF2C õexpression in contrast to what would be expected with a mechanism dependent on p38α MAPK inhibition[1].
TA-02 induces T/Brachyury whereas SB203580 addition increased MESP1 and T/Brachyury transcripts[1].
TA-02 significantly induces high NKX2-5 expression when applied between days 0-8[1].
TA-02 is found to inhibit multiple targets with similar potency to p38α MAPK, such as p38α, p38β, JNK3, JNK2, CIT, CK1ε, DMPK2, JNK1, DDR1 CK1δ, MEK5, and ERBB2[1].
TA-02 and SB203580 reduce the nuclear TCF/LEF-1 driven transcription of luciferase similar to DKK-1[1].
TA-02 (5 nM-5 μM) inhibits p38 and increases the anti-inflammation effects of BDNF on inflammation in vitro[2].

Western Blot Analysis[2]

Cell Line: The nerve cell line AGE1.HN.
Concentration: 5 nM-5 μM.
Incubation Time: 44 h (100 ng/ml LPS for 4 h at 37°C).
Result: Suppressed p-38 protein expression, reduced IL-1β, IL-6, IL-18 and TNF-α levels and inhibited iNOS and COX-2 levels in an in vitro model of SCI by BDNF overexpression, compared with the BDNF overexpression group.
Molecular Weight

333.33

Formula

C₂₀H₁₃F₂N₃

CAS No.

1784751-19-4

SMILES

FC(C=C1)=CC=C1C2=C(C3=CC=NC=C3)NC(C4=CC=CC=C4F)=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (75.00 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0000 mL 15.0002 mL 30.0003 mL
5 mM 0.6000 mL 3.0000 mL 6.0001 mL
10 mM 0.3000 mL 1.5000 mL 3.0000 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TA-02TA02TA 02p38 MAPKAutophagyTCFLEF-1BDNFCOX-2JNK3JNK2CITCK1εDMPK2JNK1DDR1 CK1δMEK5Inhibitorinhibitorinhibit

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TA-02
Cat. No.:
HY-100115
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