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Referencia número: HY-155972A

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CRM1-IN-2

CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis.

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No. CAS: 3032506-81-0
Fòrmula: C₂₉H₄₈N₂O₅
Peso molecular:504.70

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CRM1-IN-2 Chemical Structure

No. CAS: 3032506-81-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.32 μM Compound: KL2	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 37595020]
RKO	IC₅₀	0.3 μM Compound: KL2	Cytotoxicity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 37595020]

Chemical Information

No. CAS 3032506-81-0
Peso molecular 504.70
Fòrmula C₂₉H₄₈N₂O₅
SMILES

[H][C@]1([C@@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Jian L,et al. Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J Med Chem. 2023 Aug 18. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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