CRM1-IN-2
CRM1-IN-2 (Compound KL2) is a noncovalent CRM1 inhibitor. CRM1-IN-2 localizes CRM1 in the nuclear periphery, depletes nuclear CRM1, and inhibits CRM1-mediated nuclear export. CRM1-IN-2 inhibits growth of colorectal cancer cells, and induces apoptosis.
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- CAS No.: 3032506-81-0
- 화학식: C29H48N2O5
- 분자량:504.70
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.32 μM
Compound: KL2
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 37595020] |
| RKO | IC50 |
0.3 μM
Compound: KL2
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Cytotoxicity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human RKO cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
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[PMID: 37595020] |
Chemical Information
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CAS No. 3032506-81-0
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분자량 504.70
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화학식 C29H48N2O5
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SMILES
[H][C@]1([C@@H](N)/C=C/C=C(C)/C[C@@H](C)/C=C(\C=C\[C@@]([H])(C[C@H](N)CC(OC)=O)O)C)O[C@@]([H])(/C=C/C)[C@@H](C)[C@@H](O)C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CRM1-IN-2 Related Classifications
HY-155972A Related Classifications
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