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Cat. No.: HY-157412

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CRM1-IN-3

CRM1-IN-3 (B28) is a noncovalent CRM1 inhibitor. CRM1-IN-3 can be used for the research of protein localization and tumor.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1114628-25-9
Formule: C₂₆H₂₆ClN₃O₃
Masse moléculaire:463.96

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CRM1-IN-3 Chemical Structure

CAS No.: 1114628-25-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

CRM1-IN-3 (B28) is a noncovalent CRM1 inhibitor. CRM1-IN-3 can be used for the research of protein localization and tumor^[1].

Chemical Information

CAS No. 1114628-25-9
Masse moléculaire 463.96
Formule C₂₆H₂₆ClN₃O₃
SMILES

O=C(NC1=CC(C(O)=O)=CC=C1N2CCN(CC2)C3=CC(C)=CC=C3C)C4=CC=C(C=C4)Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology Molecular Biology

Antibody-based immunofluorescence/immunocytochemistry staining
Antibody-based immunofluorescence/immunocytochemistry detects the cellular or subcellular localization of a target antigen by binding a primary antibody to the target and detecting that antibody directly with a fluorophore-conjugated primary antibody or indirectly with a fluorophore-conjugated secondary antibody. Indirect immunofluorescence can amplify signal because multiple secondary antibodies can bind one primary antibody. The assay readout is fluorescence intensity and localization measured by fluorescence or confocal microscopy, and the result reflects antigen distribution only when the antibody has been validated for the target, sample type, fixation condition, and imaging workflow. Antibody specificity must not be assumed from catalog information alone, and appropriate validation or control experiments are required for serious interpretation.
Immunocytochemistry/Immunofluorescence

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Li C, et al. Discovery of a Hidden Pocket beneath the NES Groove by Novel Noncovalent CRM1 Inhibitors. J Med Chem. 2023 Dec 18. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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