1. Membrane Transporter/Ion Channel
  2. CRM1
  3. Eltanexor Z-isomer

Eltanexor Z-isomer (Synonyms: KPT-8602 (Z-isomer))

Cat. No.: HY-100423A Purity: 95.47%
Handling Instructions

Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602.

For research use only. We do not sell to patients.

Eltanexor Z-isomer Chemical Structure

Eltanexor Z-isomer Chemical Structure

CAS No. : 1642300-78-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 328 In-stock
Estimated Time of Arrival: December 31
1 mg USD 168 In-stock
Estimated Time of Arrival: December 31
5 mg USD 348 In-stock
Estimated Time of Arrival: December 31
10 mg USD 468 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1380 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Eltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor. IC50: In Vitro: Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively[1]. In Vivo:

Molecular Weight

428.29

Formula

C₁₇H₁₀F₆N₆O

CAS No.

1642300-78-4

SMILES

O=C(N)/C(C1=CN=CN=C1)=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (116.74 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3349 mL 11.6743 mL 23.3487 mL
5 mM 0.4670 mL 2.3349 mL 4.6697 mL
10 mM 0.2335 mL 1.1674 mL 2.3349 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (6.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Eltanexor Z-isomerKPT-8602 (Z-isomer)CRM1Chromosomal Maintenance 1Exportin 1XPO1Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Eltanexor Z-isomer
Cat. No.:
HY-100423A
Quantity:
MCE Japan Authorized Agent: