1. Membrane Transporter/Ion Channel
  2. CRM1

KPT-8602 

Cat. No.: HY-100423 Purity: 99.68%
Data Sheet SDS Handling Instructions

KPT-8602 is a second-generation exportin-1 inhibitor, shows similar in vitro potency compared with KPT-330.

For research use only. We do not sell to patients.
KPT-8602 Chemical Structure

KPT-8602 Chemical Structure

CAS No. : 1642300-52-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $226 In-stock
1 mg $80 In-stock
5 mg $240 In-stock
10 mg $350 In-stock
50 mg $950 In-stock
100 mg $1350 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

KPT-8602 is a second-generation exportin-1 inhibitor, shows similar in vitro potency compared with KPT-330. In vitro: KPT-8602 induces caspase-dependent apoptosis in a panel of leukemic cell lines in vitro. Using CRISPR/Cas9 genome editing we demonstrats the specificity of KPT-8602 for cysteine 528 in the cargo-binding groove of XPO1 and validats the drug target interaction. [1] In vivo: KPT-8602 shows potent anti-leukemia activity in a mouse ALL model as well as in patient-derived T- and B-ALL xenograft models without affecting normal hematopoiesis.[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3349 mL 11.6743 mL 23.3487 mL
5 mM 0.4670 mL 2.3349 mL 4.6697 mL
10 mM 0.2335 mL 1.1674 mL 2.3349 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

428.29

Formula

C₁₇H₁₀F₆N₆O

CAS No.

1642300-52-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 4.72 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.68%

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Product Name:
KPT-8602
Cat. No.:
HY-100423
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